The animation illustrates the binding of single stranded DNA to E. coli topoisomerase III. The animation was based on the structure of several intermediates obtained by x-ray crystallography. It is meant to illustrate a possible way the protein recognizes DNA and forms a competent active site by a series of conformational changes in both the protein and DNA.
The Center for Structural Biology
Department of Molecular Biosciences
2205 Tech Drive Hogan 2-100
Evanston IL 60208
phone: 847.491.7078 fax: 847.467.6489 email CSB