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Armadillo
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  {Models}
Symbol: Arm Flybase ID: {Flybase_ID}
Synonyms: {Name} {GadFly}
Function: {Short_Function} {LocusLink}
Keywords: {Keywords} {Interactive_Fly}


{Summary}
Function/Pathway
  • arm is a downstream effector of wingless signal transduction and is also a component of Cadherin-based adhesion complexes (Orsulic, 1996)
Genetic interactions
  • DE-Cadherin
    • Armadillo is titrated out of its signaling pool when DE-Cadherin is overexpressed, and in the embryonic epidermis, this leads to a phenocopy of a wingless mutation (Sanson, 1996).
      • Overexpressed Cadherin blocks the response to Wingless in a cell-autonomous manner
    • clones of cells expressing DE-Cadherin, which blocks wg signaling, located in naked regions make ectopic denticles. Clones within the denticle belts have no effect (Sanson, 1999)
  • Ectopic expression of Wg, Dsh, or a dominant-active form of Arm (ArmS10) in a fu1 mutant driven in the wing pouch by 71B-GAL4 results in a decrease in Col expression (Fig 5) (Glise, 2002)
Physical interactions
{Physical interactions}
Transcriptional Regulation
{Regulation}
Structure
{Structure}
Location (protein and transcript)
{Location}
Protein Modifications and Regulation
{Modifications}
Related to
{Related to}
Mutations
{Mutations}
Overexpression / Ectopic expression
  • Ectopic expression of Wg, Dsh, or a dominant-active form of Arm (ArmS10) in a fu1 mutant driven in the wing pouch by 71B-GAL4 results in a decrease in Col expression (Fig 5) (Glise, 2002)
Reagents
{Reagents}


 

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