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Cut
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  {Models}
Symbol: {Links} Flybase ID: {Flybase_ID}
Synonyms: {Name} {GadFly}
Function: {Short_Function} {LocusLink}
Keywords: {Keywords} {Interactive_Fly}


{Summary}
Function/Pathway
  • transcription factor
Genetic interactions
  • Likely a direct Vg-Sd target
Physical interactions
  • The Sd TEA/ATTS domain has been shown to bind to ct wing margin enhancer DNA sequence
Transcriptional Regulation
  • Regulated by Notch signaling
  • Enhancer: express in wing pouch (Kuhnlein, 1997)
Structure
  • The Cut protein is a homeodomain homolog. Although it is the most divergent of all Drosophila homeodomain proteins, it shows identity at the nine residues that are invariant in all homeodomain proteins. There are three 60 residue repeats showing 55-68% identity to each other which are not homologous to repeats found in other proteins. These are known as the Cut repeats. There are also four stretches of polyglutamate/aspartate and a number of runs rich in single amino acids (Blochlinger, 1988; Aufiero, 1994).
Location (protein and transcript)
  • Expressed in a stripe along the dorsoventral compartment boundary
  • nuclear
Protein Modifications and Regulation
{Modifications}
Related to
  • Although it is the most divergent of all Drosophila homeodomain proteins, it shows identity at the nine residues that are invariant in all homeodomain proteins. There are three 60 residue repeats showing 55-68% identity to each other which are not homologous to repeats found in other proteins.
Mutations
{Mutations}
Overexpression / Ectopic expression
{Overexpression}
Reagents
{Reagents}


 

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