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Dispatched
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  {Models}
Symbol: Symbol: Disp {Links} Flybase ID: {Flybase_ID}
Synonyms: {Name} {GadFly}
Function: {Short_Function} {LocusLink}
Keywords: {Keywords} {Interactive_Fly}


{Summary}
Function/Pathway
  • Disp is required only in P cells for effective Hh signaling to A cells. In the absence of Disp, Hh is retained in P cells, and its access to A cells is severely limited. In contrast, Hh-Nu is unaffected by the absence of Disp, indicating that the cholesterol anchor is responsible for the retention of Hh in disp mutant cells. Our results indicate that Hh-Np is indeed a tethered protein but that its retention is overcome by the activity of the dedicated SSD (sterol-sensing domain) protein, Disp. (Burke, 1999)
  • Only needed in Hh producing cells (Burke, 1999)
  • (Burke, 1999) suggest that Disp acts in some way to displace Hh-Np from the lipid rafts to which it is targeted by its cholesterol moiety.
Genetic interactions
{Genetic interations}
Physical interactions
{Physical interactions}
Transcriptional Regulation
{Regulation}
Structure
{Structure}
Location (protein and transcript)
{Location}
Protein Modifications and Regulation
{Modifications}
Related to
  • Share structural homology with Ptc in the form of a sterol-sensing domain
    • Possession of an SSD suggests a role in vesicle trafficking, or like its C. elegans counterpart CHE14 (Michaux, 2000), Disp might plays a role in apico–basal sorting of Hh.
Mutations
  • In the absence of Disp, cholesterol-modified but not cholesterol-free Hh is retained in P cells, indicating that Disp fxns to release cholesterol-anchored Hh (Burke, 1999)
Overexpression / Ectopic expression
{Overexpression}
Reagents
{Reagents}


 

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