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Small Molecule Compound Libraries
As a screening resource Northwestern's High Throughput Analysis Lab houses a number of small molecule compound libraries for use by Northwestern researchers. We are in the first phase in our effort to build a world class depository of chemical compounds for drug discovery.
Resources:
ChemDiv Structural-Diversity Set: The library includes 30,000 compounds of diverse chemical structure.
ChemBridge Drug-Like Set: The library includes 20,000 compounds of diverse chemical structure.
ASDI Library: 6800 compounds of diverse chemical structure.
NCC Set: The NIH Clinical Collection prepared by BioFocus DPI includes compounds currently in NIH clinical trials. Includes over 400 compounds.
Silverman Collection: A variety of compounds custom synthesized for screening in specific projects.
Spectrum Collection: The collection is composed of 2000 compounds from MicroSource Discovery Systems and covers; (i) drugs that have been introduced in the US, Europe and Japan and have known pharmacological profiles, (ii) natural products with unknown biological properties and (iii) other bioactive compounds such as non-drug enzyme inhibitors, receptor blockers, membrane active compounds, and cellular toxins.
The NCI/DTP Open Chemical Repository: The HTA has acquired four sets of synthetic compounds and natural products from the National Cancer Institute: the structural diversity set, the mechanistic set, the natural products set, and the challenge set, in all totally over 3200 compounds. They are free to use in screens by Northwestern researchers who are affiliated with the Lurie Comprehensive Cancer Center. We plan to acquire the 140,000 compound NCI library when our storage system is in place.
Please visit the other Library Screening pages:
