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Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI. Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Aging Cell. Cell Rep. 2017 Nov 7;21(6):1481-1494. doi: 10.1016/j.celrep.2017.10.038. (2017) pdf icon

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Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL Morimoto RI, Bukau B, Nillegoda NB. In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Aging Cell. DOI: 10.1111/acel.12686. Published online 10 October 2017. pdf icon

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Alves LGA, Winter PB, Ferreira LN, Brielmann RM, Morimoto RI, Amaral LAN. Long-range correlations and fractal dynamics in C. elegans: Changes with aging and stress. Phys Rev E. 2017 Aug;96(2-1):022417. doi: 10.1103/PhysRevE.96.022417. Epub 2017 Aug 29. (2017). pdf icon

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Li J, Labbadia J, Morimoto RI. Rethinking HSF1 in Stress, Development, and Organismal Health. Trends Cell Biol. 2017 Sep 7. pii: S0962-8924(17)30139-3. doi: 10.1016/j.tcb.2017.08.002. [Epub ahead of print]. Review. (2017). pdf icon

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Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10. (2017). pdf icon

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Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M. Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. PNAS USA. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26. (2017). pdf icon

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Sala AJ, Bott LC, Morimoto RI. Shaping proteostasis at the cellular, tissue, and organismal level. J Cell Biol. 2017 Apr 11. pii: jcb.201612111. doi: 10.1083/jcb.201612111. [Epub ahead of print] Review. (2017). pdf icon

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Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ. Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proc Natl Acad Sci U S A. 2017 Apr 10. pii: 201613854. doi: 10.1073/pnas.1613854114. (2017). pdf icon

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Winter, P., Brielmann, R., Timkovich, N., Navarro, H.,Teixeira-Castro, A., Morimoto R.I. and Amaral, L.A.N. A network approach to discerning the identities of C. elegans in a free moving population. Scientific Reports 6:34859, DOI: 10.1038 (2016). pdf icon

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Li, J., Chauve, L., Phelps, G., Brielmann, R. and Morimoto R.I. E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response. Genes and Development 30:2062-2075 (2016). pdf icon

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Ciryam, P., Kundra, R., Freer, R., Morimoto R.I., Dobson, C.M., and Vendruscolo, M. A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proc Nat Acad Sci U S A 113(17) 4753-4758 (2016). pdf icon

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Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva-Fernandes A, Neto MF, Brielmann RM, Bessa C, Duarte-Silva S, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, Silverman RB, Oliveira P, Morimoto RI, Maciel P. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain 2015: 138: 3221-3237. pdf icon

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Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B. Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nature 524, 247-251 (13 August 2015). Published online 05 August 2015. pdf icon

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Kirstein, J., D. Morito, T. Kakihana, M. Sugihara, A. Minnen, M.S. Hipp, C. Nussbaum-Krammer, F.U. Hartl, K. Nagata and R. I. Morimoto. Proteotoxic Stress and Ageing Triggers the Loss of Redox Homeostasis Across Cellular Compartments. The EMBO Journal. Pulished online July 29, 2015. pdf icon

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Labbadia, J. and R. I. Morimoto. Repression of the Heat Shock Response is a Programmed Event at the Onset of Reproduction. Molecular Cell 59, 1-12, http://dx.doi.org/10.1016/j.molcel.2015.06.0 (2015). pdf icon

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Brandvold, KR and RI Morimoto. The Chemical Biology of Molecular Chaperones-Implications for Modulation of Proteostasis. J Mol Biol (2015) 427, 2931- 2947. Review. pdf icon

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Walther, D.M., P. Kasturi, M. Zheng, S. Pinkert, G. Vecchi, P. Ciryam, R. I. Morimoto, C. M. Dobson, M. Vendruscolo, M. Mann, and F.U. Hartl. Widespread Proteome Remodeling and Aggregation in C. elegans. Cell 161, 919–932 May 7, 2015 a2015 Elsevier Inc. http://dx.doi.org/10.1016/j.cell.2015.03.032 (2015). pdf icon

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Ciryam, P., R. Kundra, R. I. Morimoto, C. M. Dobson, and M. Vendruscolo. Supersaturation is a Driving Force for Protein Aggregation in Neurodegenerative Diseases. Trends in Pharmacological Sciences, 36: 72-77, DOI:10.1016/j.tips.2014.12.004 (2015). pdf icon

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Labbadia, J., and R.I. Morimoto. The Biology of Proteostasis in Aging and Disease. Annual Reviews of Biochemistry, 84:32.1–32.30, doi: 10.1146/annurev-biochem-060614-033955 (2015). pdf icon

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Tatum, M.C., Ooi, F.K., Madhusudana, R.C., Chauve, L., Martinez-Velazquez, L.A., Steinbusch, H.W.M., Morimoto, R.I. and V. Prahlad. Neuronal Serotonin Release Triggers the Heat Shock Response in C. elegans in the Absence of Temperature Increase, Current Biology (2015), http://dx.doi.org/10.1016/j.cub.2014.11.040 pdf icon

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Nussbaum-Krammer, C. I., Neto, M. F., Brielmann, R. M., Pedersen, J. S., Morimoto, R. I. Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans. J. Vis. Exp. (95), e52321, doi:10.3791/52321 (2015). pdf icon

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Roth, D.M., D.M. Hutt, J. Tong, M. Bouchecareilh, N. Wang, T. Seeley, J.F. Dekkers, J.M. Beekman, D. Garza, L. Drew, E. Masliah, R.I. Morimoto, W.E. Balch. Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding. PLOS Biology 12(11): e1001998. doi:10.1371/journal.pbio.1001998 (2014) . pdf icon

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Kennedy, B., S.L. Berger, A. Brunet, J. Campisi, AM Cuervo, E.S. Epel, C. Franceschi, G.J. Lithgow, R.I. Morimoto, J.E. Pessin, T.A. Rando, A. Richardson, E.E. Schadt, T. Wyss-Coray, F. Sierra. Geroscience: Linking Aging to Chronic Disease. Cell 159 (2014). pdf icon

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Brehme, M., C. Voisine, T. Rolland, S. Wachi, J.H. Soper, Y. Zhu, K. Orton, A. Villella, D. Garza, M. Vidal, H. Ge and R.I. Morimoto. A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease. Cell Reports (2014) http://dx.doi.org/10.1016/j.celrep.2014.09.042. pdf icon

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van Oosten-Hawle, P., and R.I. Morimoto. Organismal Control of Proteostasis by Cell Non-Autonomous Regulation and Transcellular Stress Signaling. Genes and Development 28: 1533-1543 (2014). pdf icon

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Trippier, P., K.T. Zhao, S.G. Fox, I. Schiefer, R. Benmohamed, J. Moran, D. Kirsch, R.I. Morimoto, and R. Silverman. Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis. ACS Chemical Neuroscience (2014). pdf icon

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Shibata, Y., and R.I. Morimoto. How the Nucleus Copes with Proteotoxic Stress. Current Biology 24 R463-474, DOI: 10.1016 (2014). pdf icon

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Ryno, L.M., J.C. Genereux, T. Naito, R.I. Morimoto, E.T. Powers, M.D. Shoulders, and R.L. Wiseman. Characterizing the Altered Cellular Proteomes Induced by the Stress-Independent Activation of Heat Shock Factor 1 to Physiologic Levels. ACS Chemical Biology (2014). pdf icon

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Morimoto, R.I., and A.M. Cuervo. Proteostasis and the Aging Proteome in Health and Disease. J. Gerontology: Biological Sciences and Medical Sciences 69(6) S33-38, DOI: 10.1093 (2014). pdf icon

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Yu, A., Y. Shibata, B. Shah, B. Calamini, D.C. Lo and R.I. Morimoto. Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proc Natl Acad Sci U S A.; 111(15):E1481-90. doi: 10.1073/pnas.1321811111. Epub 2014 Apr 1. (2014). pdf icondivider

Labbadia, J. and R.I. Morimoto. Proteostasis and Longevity: When Does Aging Begin? F1000 Prime Reports 6:06 DOI: 10.12703 (2014). pdf icon

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Kitamura, A., N. Inada, H. Kubota, G. Matsumoto, M. Kinjo, R.I. Morimoto, and K. Nagata. Dysregulation of the Proteosome Increases the Toxicity of ALS-Linked Mutant SOD1. Genes to Cells DOI: 10.1111 (2014). pdf icon

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Nussbaum-Krammer, C., and R.I. Morimoto. Caenorhabditis elegans as a Model System for Cell Non-Autonomous Mechanisms in Protein Misfolding Diseases. Disease Models and Mechanisms 7: 31-39, DOI: 10.1242 (2014). pdf icon

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van Oosten-Hawle and R. I. Morimoto. Transcellular Chaperone Signaling: An Organismal Strategy for Integrated Cell Stress Responses. Journal of Experimental Biology 217: 129-136, DOI: 10.1242 (2014). pdf icon

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Kirstein-Miles, J., and R.I. Morimoto. Ribosome-Associated Chaperones act as Proteostasis Sentinels. Cell Cycle. 12 (15): PMID: 23856581 (2013). pdf icon

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Bersuker, K., M. S. Hipp, B. Calamini, R.I. Morimoto, and R. R. Kopito. Heat Shock Response Activation Exacerbates Inclusion Body Formation in a Cellular Model of Huntington’s Disease J. Biol. Chem. 288 (33): 23633-23638, DOI:10.1074 (2013). pdf icon

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Ciryam, P., Tartaglia, G.G., Morimoto, R.I., Dobson, C.M., and Vendruscolo, M. Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins, Cell Reports (2013), http://dx.doi.org/10.1016/j.celrep.2013.09.043 pdf icon

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Gidaevitz, T., Wang, N., Devaraj, T., Alexander-Floyd, J. and R.I. Morimoto. Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease. BMC Biology 2013, 11:100. pdf icon

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Silva, C.M., Amaral, M.D. and R.I. Morimoto. (2013). Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response. PLoS Genet 9(8): e1003711. doi:10.1371/journal.pgen.1003711. pdf icon

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Labbadia, J. and R.I. Morimoto. Huntington's disease: underlying molecular mechanisms and emerging concepts. Trends Biochem Sci. 2013 Aug;38(8):378-85. doi: 10.1016/j.tibs.2013.05.003. Epub 2013 Jun 12. Review. pdf icon

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van Oosten-Hawle, P., Porter, R.S., and R.I. Morimoto. Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling. Cell 153, 1366–1378. Epub 6 June 2013. pdf icon

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Kirstein-Miles, J., Scior, A., Deuerling, E., Morimoto, R. (2013) The nascent polypeptide-associated complex is a key regulator of proteostasis. The EMBO Journal. 2013 May 15;32(10):1451-68. doi: 10.1038/emboj.2013.87. Epub 2013 Apr 19.pdf icon

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Guisbert E, Czyz DM, Richter K, McMullen PD, Morimoto RI (2013) Identification of a Tissue-Selective Heat Shock Response Regulatory Network. PLoS Genet 9(4): e1003466. doi:10.1371/journal.pgen.1003466. Epub 2013 Apr 18pdf icon

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Nussbaum-Krammer CI, Park K-W, Li L, Melki R, Morimoto RI (2013) Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans. PLoS Genet 9(3): e1003351. doi:10.1371/journal.pgen.1003351. Epub 2013 Mar 28. pdf icon

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Zhang Y, Benmohamed R, Huang H, Chen T, Voisine C, Morimoto RI, Kirsch DR, Silverman RB. Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. J Med Chem. 2013 Mar 28;56(6):2665-75. doi: 10.1021/jm400079a. Epub 2013 Mar 15. pdf icon

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Calamini, B. and Morimoto R.I. Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation. Current Topics in Medicinal Chemistry. 2012, 12(22):2623-2640. pdf icon

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Ciryam P, Morimoto RI, Vendruscolo M, Dobson CM, O'Brien EP. In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E132-40. doi: 10.1073/pnas.1213624110. Epub 2012 Dec 19. pdf icon

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Rampelt H, Kirstein-Miles J, Nillegoda NB, Chi K, Scholz SR, Morimoto RI, Bukau B. Metazoan Hsp70 machines use Hsp110 to power protein disaggregation. EMBO J. 2012 Sep 18. doi: 10.1038/emboj.2012.264. [Epub ahead of print]. pdf icon

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Zhang Y, Benmohamed R, Zhang W, Kim J, Edgerly CK, Zhu Y, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS. ACS Med Chem Lett. 2012 May 22;3(7):584-587. pdf icon

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Beam, M, Silva, MC, Morimoto, RI. Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo. J Biol Chem. 2012 Jul 27;287(31):26136-45. Epub 2012 Jun 5. pdf icon

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Klaic, L, Morimoto, RI, Silverman, RB Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. ACS Chem Biol. 2012 May 18;7(5):928-37. Epub 2012 Mar 14. pdf icon

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Morimoto, RI. The Heat Shock Response: Systems Biology of Proteotoxic Stress Stress in Aging and Disease. Cold Spring Harb Symp Quant Biol. 2011;76:91-9. Epub 2012 Feb 27 pdf icon

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McMullen PD, Aprison EZ, Winter PB, Amaral LAN, Morimoto RI., Ruvinsky, I. (2012) Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress. PLoS Comput Biol 8(1): e1002338. doi:10.1371/journal.pcbi.1002338pdf icon

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Silva MC, Fox S., Beam M, Thakkar H., Amaral MD and Morimoto RI. A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network. PLOS Genetics 7(12): e1002438. doi:10.1371/journal.pgen.1002438. 2011 Dec 29. pdf icon

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Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, Morimoto RI. Small molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8(2):185-96. doi: 10.1038/nchembio.763.pdf icon

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Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB. ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis. J. Med. Chem. 2012 Jan 12;55(1):515-27. doi: 10.1021/jm2014277. Epub 2011 Dec 22..pdf icon

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Zhang W, Benmohamed R, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorg Med Chem. 2011 Nov 30. [Epub ahead of print]pdf icon

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Klaic L, Trippier PC, Mishra RK, Morimoto RI, Silverman RB. Remarkable stereospecific conjugate additions to the hsp90 inhibitor celastrol. J Am Chem Soc. 2011 Dec 14;133(49):19634-7. Epub 2011 Nov 21.pdf icon

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Prahlad, V. and Morimoto, R.I. Neuronal Circuitry Regulates the Response of Caenorhabditis Elegans to Misfolded Proteins. Proc Natl Acad Sci USA. 108: 14204-14209 (2011).pdf icon

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Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaça JL, Dias N, Rodrigues P, Oliveira JF, Neves-Carvalho A, Morimoto RI, Maciel P. Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet. 20(15):2996-3009. Epub May 5 (2011).pdf icon

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Gidalevitz T, Prahlad V, Morimoto RI. The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms. Cold Spring Harb Perspect Biol. 2011 May 2. pii: cshperspect.a009704v1. doi: 10.1101/cshperspect.a009704. [Epub ahead of print]pdf icon

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Petre, I., C.L. Hyder, A. Mizera, A. Meinander, A. Mikhailov, R.I. Morimoto, L. Sistonen, J.E. Eriksson, and R-J. Back. A Simple Mass-Action Model for the Eukaryotic Heat Shock Response and its Mathematic Validation. Natural Computing, 10: 595-612, DOI: 10.1007/s11047-010-9216-y (2011) pdf icon

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Xia G, Benmohamed R, Kim J, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. J Med Chem. 2011 Apr 14;54(7):2409-21. Epub 2011 Mar 4.pdf icon

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Morimoto RI, Driessen AJ, Hegde RS, Langer T. The life of proteins: the good, the mostly good and the ugly. Nat Struct Mol Biol. 2011 Jan;18(1):1-4.pdf icon

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Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB. Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorg Med Chem. 2011 Jan 1;19(1):613-22. Epub 2010 Oct 30.pdf icon

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Benmohamed R, Arvanites AC, Kim J, Ferrante RJ, Silverman RB, Morimoto RI, Kirsch DR. Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 Mar;12(2):87-96. Epub 2010 Nov 12.pdf icon

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Kikis EA, Gidalevitz T, Morimoto RI. Protein homeostasis in models of aging and age-related conformational disease. Adv Exp Med Biol. 2010;694:138-59. Review.pdf icon

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Akerfelt, Malin, Morimoto, R.I. and Lea Sistonen. Heat Shock Factors: Integrators of Cell Stress, Development and Lifespan. Nat Rev Mol Cell Biol. 2010 Aug;11(8):545-55. Epub 2010 Jul 14. Review.pdf icon

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McMullen, Patrick D., Morimoto, R.I. and Luis A. Nunes Amaral. Physically Grounded Approach for Estimating Gene Expression from Microarray Data. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13690-5. Epub 2010 Jul 19.pdf icon

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Voisine C, Pedersen JS, Morimoto RI. Chaperone networks: tipping the balance in protein folding diseases. Neurobiol Dis. 2010 Oct;40(1):12-20. Epub 2010 May 21. Review.pdf icon

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Kirstein-Miles, J. and R.I. Morimoto. Caenorhabditis elegans as a Model System to Study Intercompartmental Proteostasis: Interrelation of Mitochondrial Function, Longevity, and Neurodegenerative Diseases. Developomental Dynamics 239: 1529-1538 (2010).pdf icon

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Kirstein-Miles, J. and R.I. Morimoto. Peptides Signal Mitochondrial Stress. Cell Metabolism 11: 177-178 (2010).pdf icon

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Gidalevitz, T., E.A. Kikis, and R.I. Morimoto. A Cellular Perspective on Conformational Disease: The Role of Genetic Background and Proteostasis Networks. Current Opinions in Structural Biology 20: 23-32 (2010). pdf icon

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Ben-Zvi, A., E.- Miller, and R.I. Morimoto. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. PNAS 106(35):14914-14919 (2009).pdf icon

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Powers, E.T., R.I. Morimoto, A. Dillin, J.W. Kelly, and W.E. Balch. Biological and Chemical Approaches to Diseases of Proteostasis Deficiency. Annual Reviews of Biochemistry 78:959-991 (2009).pdf icon

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Sharabi K, Hurwitz A, Simon AJ, Beitel GJ, Morimoto RI, Rechavi G, Sznajder JI, Gruenbaum Y. Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 106(10): 4024-29 (2009). pdf icon

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Gidalevitz, T., T. Krupinski, S. Garcia, and R.I. Morimoto. Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity. PLoS Genet 5(3): e1000399 (2009). pdf icon

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Westerheide, S.D., J. Anckar, S.M. Stevens, Jr., L. Sistonen, and R.I. Morimoto. Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1. Science 20: 1063-1066 (2009). pdf icon

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Prahlad, V., and R.I. Morimoto. Integrating the Stress Response: Lessons for Neurodegenerative Diseases from C. elegans. Trends in Cell Biology 19: 52-61 (2009). PMID: 19112021 [PubMed - as supplied by publisher] pdf icon

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Morimoto R.I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Review. Genes and Development 22:1427-1438 (2008). pdf icon

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Prahlad, V., T. Cornelius and R.I. Morimoto. Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons. Science 320: 811-814 (2008). pdf icon

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Trott A., J.D. West, L. Klaic, S.D. Westerheide, R.B. Silverman, R.I. Morimoto, and K.A. Morano. Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule. Molecular Biology of the Cell 19: 1104-1112 (2008). pdf icon

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Balch, W.E., R.I. Morimoto, A. Dillin, and J.W. Kelly. Adapting proteostasis for disease intervention. Review. Science 319 (5865): 916-919 (2008). pdf icon

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Garcia, S. M., M.O. Casanueva, M.C. Silva, M.D. Amaral, and R.I. Morimoto. Neuronal signaling modulates protein homeostasis in C. elegans postsynaptic muscle cells. Genes and Development 21: 3006-3016 (2007). pdf icon

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Zourlidou, A. T. Gidalevitz, M. Kristiansen , C. Landles, B. Woodman, D. J. Wells, D. S. Latchman, J. de Belleroche, S. J. Tabrizi, R. I. Morimoto and G. P. Bates. Hsp27 overexpression in the R6/2 mouse model of Huntington’s Disease: Chronic Neurodegeneration does not Induce Hsp27 Activation. Hum. Mol. Genet. Advance Access (2007). pdf icon

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Brignull, H.R., J.F. Morley, and R.I. Morimoto. The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging. (Ed. P. Csermly and L. Vigh) Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks, 594: 167-189, Landes Bioscience (2007). pdf icon

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Finkbeiner, S., A.M. Cuervo, R.I. Morimoto and P.J. Muchowski. Disease-modifiying pathways in neurodegeneration. The Journal of Neuroscience 26(41): 10349-10357 (2006). pdf icon

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Brignull, H.R., J.F. Morley, S.M. Garcia, and R.I. Morimoto. Modeling Polyglutamine Pathogenesis in C. elegans. Methods in Enzymology 412: 256-282 (2006). pdf icon

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Morimoto, R.I. Stress, Aging and Neurodegenerative Disease. The New England Journal of Medicine 355(21): 2254-2255 (2006). pdf icon

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Kitamura, A., H. Kubota, C. Pack, G. Matsumoto, S. Hirayama, Y. Takahashi, H. Kimura., M. Kinjo, R. I. Morimoto and K. Nagata. Cytosolic Chaperonin Prevents Polyglutamine Toxicity with Altering the Aggregation State. Nature Cell Biology 8(10):1163-1175 (2006). pdf icon

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Brignull, H., F. Moore, S. Tang, and R. I. Morimoto. Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal Caenorhabditis elegans Model. The Journal of Neuroscience 26(29): 7597-7606 (2006). pdf icon

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Gidalevitz, T., A. Ben-Zvi, K. Ho, H. Brignull, and R. I. Morimoto. Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases . Science 311: 1471-1474 (2006). pdf icon

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Westerheide, S., T. Kawahara, K. Orton, and R.I. Morimoto. Triptolide, an Inhibitor of the Human Heat Shock Response that Enhances Stress-Induced Cell Death. J. Biol. Chem. 281: 9616-9622 (2006).pdf icon

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Matsumoto, G., S. Kim, and R.I. Morimoto. Huntingtin and mutant SOD1 form aggregate structures with distinct molecular properties in human cells. J Biol Chem. 281: 4477-4485 (2006). pdf icon

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Matsumoto, G., A. Stojanovic, C. Holmberg, S. Kim, and R.I. Morimoto. Structural Properties and Neuronal Toxicity of Amyotrophic Lateral Sclerosis-Associated Cu/Zn Superoxide Dismutase 1 Aggregates. J. Cell Biology 171: 75-85 (2005). pdf icon

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Rieger TR, Morimoto RI, and V. Hatzimanikatis. Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo. Biophys J. 90: 886-95 (2006). pdf icon

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Westerheide, S., and R.I. Morimoto. Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation. J. Biol. Chem. 380: 33097-33100 (2005).pdf icon

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Rieger, T., R.I. Morimoto, and V. Hatzimanikatis. Mathematical Modeling of the Eukaryotic Heat Shock Response: Dynamics of the Hsp70 Promoter. Biophysical Journal 88: 1646-1658 (2005). pdf icon

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Holmberg, C., K. Staniszewski, K. Mensah, A. Chavez, A. Matouschek, and R.I. Morimoto. Inefficient Degradation of Truncated Polyglutamine Proteins by the Proteasome. EMBO Journal 23: 4307-4318 (2004). pdf icon

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Westerheide, S., J. Bosman, B. Mbadugha, T. Kawahara, G. Matsumoto, W. Gu, S. Kim, J. Devlin, R. Silverman, and R.I. Morimoto. Celastrols as Inducers of the Heat Shock Response and Cytoprotection J. Biol. Chem. 279: 56053-60 (2004). pdf icon

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Solomon A, Bandhakavi S, Jabbar S, Shah R, Beitel GJ, Morimoto RI. Caenorhabditis elegans OSR-1 Regulates Behavioral and Physiological Responses to Hyperosmotic Environments. Genetics, 167: 161-170 (2004). pdf icon

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Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A, 101: 6403-6408 (2004). pdf icon

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Mosser DD, Morimoto RI. Molecular chaperones and the stress of oncogenesis. Oncogene, 23(16):2907-18 (2004). pdf icon

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Morley, J.F. and Morimoto, R. Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones. Mol Biol Cell. Feb;15:657-64 (2004). pdf icon

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Colon-Ramos DA, Irusta PM, Gan EC, Olson MR, Song J, Morimoto RI, Elliott RM, Lombard M, Hollingsworth R, Hardwick JM, Smith GK, Kornbluth S. Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell. Oct;14:4162-72 (2003). pdf icon

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Soojin Kim, Ellen A. A. Nollen, Kazunori Kitagawa, Vytautas P. Bindokas and Richard I. Morimoto. Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4: 826-831 (2002). pdf icon

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Morimoto, R.I. Dynamic Remodeling of Transcription Complexes by Molecular Chaperones. Cell 110: 1–20 (2002). pdf icon

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Morley J.F., Brignull H.R., Weyers J.J., Morimoto R.I. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. (2002). pdf icon

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Nollen EA, Morimoto RI. Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J Cell Sci. 115: 2809-16 (2002). pdf icon

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Jolly, C., L. Konecny, D.L. Grady, Y.A. Kutskova, J.J. Cotto, R.I. Morimoto, and C. Vourch. In vivo Binding of Active HSF1 to Human Chromosome 9 Heterochromatin During Stress. J. Cell Biology 156: 775-781 (2002). pdf icon

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Nollen, E.A.A. and R.I. Morimoto. Cellular and Molecular Response to Stress, Misfolded Proteins, and Diseases of Protein Misfolding (ed. T. Creighton), Encyclopedia of Molecular Medicine, p. 1553-1563, Wiley Press (2002).pdf icon

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Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107:893-903 (2001). pdf icon

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Tai LJ, McFall SM, Huang K, Demeler B, Fox SG, Brubaker K, Radhakrishnan I, Morimoto RI. Structure-function analysis of the heat shock factor binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. J Biol Chem. (2001). pdf icon

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Mathew A, Mathur SK, Jolly C, Fox SG, Kim S, Morimoto RI. Stress-specific activation and repression of heat shock factors 1 and 2. Mol Cell Biol. 21: 7163-71 (2001). pdf icon

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Ahn SG, Liu PC, Klyachko K, Morimoto RI, Thiele DJ. The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress. Genes Dev.15: 2134-45 (2001). pdf icon

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Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20: 3800-10 (2001). pdf icon

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Carr, Menco, Yankova, Morimoto, and Farbman. Odorants as Cell-Type Specific Activators of a Heat Shock Response in the Rat Olfactory Mucosa. Journal of Comparative Neurology 432: 425-439 (2001). pdf icon

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Thress K, Song J, Morimoto RI, Kornbluth S. Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. EMBO J 1:1033-1041 (2001). pdf icon

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Song, J, Takeda M and Morimoto RI. Hsp70-Bag1 complex mediates a physiological stress signaling pathway that regulates Raf-1/ERK and cell growth. Nature Cell Biology 3: 276-282 (2001). pdf icon

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Jolly C and Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. Journal of the National Cancer Institute 92:1564-1572, 2000. pdf icon

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Mosser, D., Caron, A.W., Bourget, L., Meriin, A.B., Sherman, M.Y., Morimoto, R.I., and Massie, B. The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis. Molecular and Cellular Biology 20: 7146-7159 (2000). pdf icon

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Beere H, Wolf B, Mosser R, Klein K, Kuwana T, Morimoto R, Cohen G and Green D Heat shock protein 70 (Hsp70) inhibits apoptosis by preventing recruitment of procaspase-9 to aggregated Apaf-1. Nature Cell Bio. 2; 469-475, 2000. pdf icon

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Satyal SH, Schmidt E, Kitagawa K, Sondheimer N, Lindquist S, Kramer JM, Morimoto RI. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci U S A 23;97(11):5750-5, 2000. pdf icon

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Freeman BC, Michels A, Son, J, Kampinga H and Morimoto RI Analysis of molecular chaperone activities using in vitro and in vivo approaches. Methods in Molecular Biology, (ed. S. Keyse), p. 393-419, Humana Press, 2000. pubmed icon

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Mathew A, Shi Y, Jolly C, Morimoto RI. Analysis of the mammalian heat-shock response. Inducible gene expression and heat-shock factor activity. Methods Mol Biol 2000. pubmed icon

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Nollen EA. Brunsting JF. Song J. Kampinga HH. Morimoto RI. Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol:20(3):1083-8, 2000. pdf icon

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Carr VM, Morimoto RI, and Farbman AI. Development and further characterization of a small subclass of rat olfactory receptor neurons that shows immunoreactivity for the HSP70 heat shock protein. J Comp Neurol., 404:375-86, 1999. pdf icon

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Super HJ. Hasenkrug KJ. Simmons S. Brooks DM. Konzek R. Sarge KD. Morimoto RI. Jenkins NA. Gilbert DJ. Copeland NG. Frankel W. Chesebro B. Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15. J Virol:73(9):7848-52, 1999. pdf icon

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Cotto JJ and Morimoto RI. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors [Review]. Biochem. Soc. Symp., 64:105-118, 1999. pubmed icon

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Montgomery DL, Morimoto RI, Gierasch LM Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling. J Mol Biol:286(3):915-32, 1999. pdf icon

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Morimoto RI. The Heat Shock Response: Regulation and Function of Molecular Chaperones. The Encyclopedia of Molecular Biology (ed. T. Creighton), p.1088-1098, Wiley Press, 1999.

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Jolly C. Morimoto RI. Stress and the cell nucleus: dynamics of gene expression and structure reorganization. Gene Expr:7(4-6):261-70, 1999. pubmed icon

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Wang SM. Khandekar JD. Kaul KL. Winchester DJ. Morimoto RI. A method for the quantitative analysis of human heat shock gene expression using a multiplex RT-PCR assay. Cell Stress & Chaperones. pdf icon

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Jolly C. Vourc'h C. Robert-Nicoud M. Morimoto RI. Intron-independent association of splicing factors with active genes. Journal of Cell Biology. 14;145(6):1133-43, 1999. pdf icon

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Jolly C. Usson Y. Morimoto RI. Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc National Academy of Science USA. 8;96(12):6769-74, 1999. pdf icon

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Osipiuk J, Walsh MA, Freeman BC, Morimoto, RI, Joachimiak, A Structure of a new crystal form of human Hsp70 ATPase domain Acta Crystallographica, D55, 1105-1107, 1999. pdf icon

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Melville MW. Tan SL. Wambach M. Song J. Morimoto RI. Katze MG. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. Journal of Biological Chemistry. 5;274(6):3797-803, 1999 . pdf icon

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Morimoto, RI. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. (Review) Genes & Development, 12:3788-3796, 1998. pdf icon

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Satyal, SH and Morimoto, R. I Biochemical events in the activation and attenuation of the heat shock transcriptional response. J. Biosci. 23: 303-311, 1998.

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Bimston D, Song J, Winchester D, Takayama S, Reed JC, Morimoto RI BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from sugstrate release EMBO 17: 6871-6878, 1998. pdf icon

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Furukawa M, Uchiumi T, Nomoto M, Takano H, Morimoto RI, Naito S, Kuwano M, Kohno K The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIalpha gene by heat shock. J Biol Chem 1998. pdf icon

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Morimoto RI, Santoro MG Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection Nat Biotechnol 1998 Sep;16(9):833-8. pdf icon

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Mathew A and Morimoto, RI. Role of the heat-shock response in the life and death of proteins. Ann NY Acad Sci., 851:99-111, 1998. pdf icon

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Mathew A, Mathur SK, Morimoto RI Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin- proteasome pathway Mol Cell Biol:18(9):5091-8, 1998. pdf icon

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Tanabe M, Kawazoe Y, Takeda S, Morimoto RI, Nagata K, Nakai A Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. EMBO J 1998 Mar 16;17(6):1750-8. pdf icon

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Shi Y, Mosser DD, Morimoto RI Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev., 12(5):654-66, 1998. pdf icon

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Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI Negative regulation of the heat shock transcriptional response by HSBP1. Genes Dev 1998 Jul 1;12(13):1962-7. pdf icon

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Jolly C. Morimoto R. Robert-Nicoud M. Vourc'h C . HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites. Journal of Cell Science. 110 ( Pt 23):2935-41, 1997. pdf icon

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Cotto J. Fox S. Morimoto R . HSF1 granules: a novel stress-induced nuclear compartment of human cells. Journal of Cell Science. 110 ( Pt 23):2925-34, 1997. pdf icon

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Morimoto RI, Kline, MP, Bimston DN and Cotto, JJ. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochm., 32:17-29, 1997. pubmed icon

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Kline MP. Morimoto RI . Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Molecular & Cellular Biology. 17(4):2107-15, 1997. pdf icon

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Rallu M. Loones M. Lallemand Y. Morimoto R. Morange M. Mezger V . Function and regulation of heat shock factor 2 during mouse embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 94(6):2392-7, 1997. pdf icon

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Takayama S. Bimston DN. Matsuzawa S. Freeman BC. Aime-Sempe C. Xie Z. Morimoto RI. Reed JC . BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO Journal. 16(16):4887-96, 1997. pdf icon

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Kimura Y. Rutherford SL. Miyata Y. Yahara I. Freeman BC. Yue L. Morimoto RI. Lindquist S . Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes & Development. 11(14):1775-85, 1997. pdf icon

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Kanei-Ishii C. Tanikawa J. Nakai A. Morimoto RI. Ishii S . Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science. 277(5323):246-8, 1997. pdf icon

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Sriram M. Osipiuk J. Freeman B. Morimoto R. Joachimiak A . Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain. Structure. 5(3):403-14, 1997. pubmed icon

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Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI and Nagata K. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol 17:469-81, 1997. pdf icon

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Freeman BC. Toft DO. Morimoto RI . Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein P23. Science 274:1718-1720, 1996.pdf icon

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Hansen S, Midgley CA, Lane DP, Freeman BC, Morimoto RI and Hupp TR. Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70. J Biol. Chem., 271: 30922-8, 1996. pdf icon

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Morimoto RI. Kroeger PE. Cotto JJ . The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions. [Review] [116 refs] EXS. 77:139-63, 1996. pubmed icon

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Freeman BC. Morimoto RI . The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. EMBO Journal. 15(12):2969-79, 1996.pdf icon

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Cotto JJ. Kline M. Morimoto RI . Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. Journal of Biological Chemistry. 271(7):3355-8, 1996. pdf icon

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Marcuccilli CJ. Mathur SK. Morimoto RI. Miller RJ. Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock. Journal of Neuroscience. 16(2):478-85, 1996. pdf icon

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Nakai A. Kawazoe Y. Tanabe M. Nagata K. Morimoto RI. The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Molecular & Cellular Biology. 15(10):5268-78, 1995. pdf icon

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Freeman BC. Myers MP. Schumacher R. Morimoto RI. Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO Journal. 14(10):2281-92, 1995. pdf icon

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Bhattacharyya T. Karnezis AN. Murphy SP. Hoang T. Freeman BC. Phillips B. Morimoto RI. Cloning and subcellular localization of human mitochondrial hsp70. Journal of Biological Chemistry. 270(4):1705-10, 1995. pdf icon

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Shi Y, Kroeger PE and Morimoto RI. The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive. Mol. Cell Biol., 15:4309-4318, 1995. pubmed icon

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Lee BS. Chen J. Angelidis C. Jurivich DA. Morimoto RI. Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage. PNAS 92(16):7207-11, 1995. pdf icon

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Carr VM. Murphy SP. Morimoto RI. Farbman AI. Small subclass of rat olfactory neurons with specific bulbar projections is reactive with monoclonal antibodies to the HSP70 heat shock protein. Journal of Comparative Neurology. 348(1):150-60, 1994. pubmed icon

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Kroeger PE. Morimoto RI. Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity. Molecular & Cellular Biology. 14(11):7592-603, 1994. pdf icon

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Jurivich DA. Sistonen L. Sarge KD. Morimoto RI. Arachidonate is a potent modulator of human heat shock gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 91(6):2280-4, 1994. pdf icon

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Sistonen L. Sarge KD. Morimoto RI. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Molecular & Cellular Biology. 14(3):2087-99, 1994. pdf icon

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Kanei-Ishii C. Yasukawa T. Morimoto RI. Ishii S. c-Myb-induced trans-activation mediated by heat shock elements without sequence-specific DNA binding of c-Myb. Journal of Biological Chemistry. 269(22):15768-75, 1994. pdf icon

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Sarge KD. Park-Sarge OK. Kirby JD. Mayo KE. Morimoto RI. Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biology of Reproduction. 50(6):1334-43, 1994. pdf icon

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Fawcett TW. Sylvester SL. Sarge KD. Morimoto RI. Holbrook NJ. Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. Journal of Biological Chemistry. 269(51):32272-8, 1994. pdf icon

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Mezger V. Rallu M. Morimoto RI. Morange M. Renard JP. Heat shock factor 2-like activity in mouse blastocysts. Developmental Biology. 166(2):819-22, 1994. pdf icon

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Mathur SK. Sistonen L. Brown IR. Murphy SP. Sarge KD. Morimoto RI. Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 91(18):8695-9, 1994. pdf icon

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Li WW. Sistonen L. Morimoto RI. Lee AS. Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element. Molecular & Cellular Biology. 14(8):5533-46, 1994. pdf icon

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Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. [Review] Science. 259(5100):1409-10, 1993. pdf icon

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Sarge KD. Murphy SP. Morimoto RI. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress [published errata appear in Mol Cell Biol 1993 May;13(5):3122-3 and 1993 Jun;13(6):3838-9]. Molecular & Cellular Biology. 13(3):1392-407, 1993. pubmed icon

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Kroeger PE. Sarge KD. Morimoto RI. Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element. Molecular & Cellular Biology. 13(6):3370-83, 1993. pdf icon

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Beere HM. Morimoto RI. Hickman JA. Investigations of mechanisms of drug-induced changes in gene expression: N-methylformamide-induced changes in synthesis of the M(r) 72,000 constitutive heat shock protein during commitment of HL-60 cells to granulocyte differentiation. Cancer Research. 53(13):3034-9, 1993. pubmed icon

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Nakai A. Morimoto RI. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Molecular & Cellular Biology. 13(4):1983-97, 1993. pubmed icon

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Sistonen L. Sarge KD. Phillips B. Abravaya K. Morimoto RI. Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Molecular & Cellular Biology. 12(9):4104-11, 1992. pubmed icon

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Morimoto RI. Sarge KD. Abravaya K. Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses. [Review] Journal of Biological Chemistry. 267(31):21987-90, 1992. pubmed icon

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Jurivich DA. Sistonen L. Kroes RA. Morimoto RI. Effect of sodium salicylate on the human heat shock response. Science. 255(5049):1243-5, 1992. pubmed icon

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Morimoto RI. Transcription factors: positive and negative regulators of cell growth and disease. [Review] Current Opinion in Cell Biology. 4(3):480-7, 1992 . pubmed icon

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Amici C. Sistonen L. Santoro MG. Morimoto RI. Antiproliferative prostaglandins activate heat shock transcription factor.Proceedings of the National Academy of Sciences of the United States of America. 89(14):6227-31, 1992. pubmed icon

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Abravaya K. Myers MP. Murphy SP. Morimoto RI. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes & Development. 6(7):1153-64, 1992. pubmed icon

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Sarge KD. Zimarino V. Holm K. Wu C. Morimoto RI. Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes & Development. 5(10):1902-11, 1991. pubmed icon

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Abravaya K. Phillips B. Morimoto RI. Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes & Development. 5(11):2117-27, 1991. pubmed icon

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Phillips B. Abravaya K. Morimoto RI. Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses. Journal of Virology. 65(11):5680-92, 1991. pubmed icon

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Kroes RA. Abravaya K. Seidenfeld J. Morimoto RI. Selective activation of human heat shock gene transcription by nitrosourea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 88(11):4825-9, 1991. pubmed icon

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Watowich SS. Morimoto RI. Lamb RA. Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene. Journal of Virology. 65(7):3590-7, 1991. pubmed icon

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Abravaya K. Phillips B. Morimoto RI. Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting. Molecular & Cellular Biology. 11(1):586-92, 1991. pubmed icon

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Koskinen PJ. Sistonen L. Evan G. Morimoto R. Alitalo K. Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells. Journal of Virology. 65(2):842-51, 1991. pubmed icon

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Morimoto RI. Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation. [Review] Cancer Cells. 3(8):295-301, 1991. pubmed icon

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Phillips B. Morimoto RI. Transcriptional regulation of human hsp70 genes: relationship between cell growth, differentiation, virus infection, and the stress response. Results & Problems in Cell Differentiation. 17:167-87, 1991. pubmed icon

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Sarge KD. Morimoto RI. Surprising features of transcriptional regulation of heat shock genes. [Review] Gene Expression. 1(3):169-73, 1991. pubmed icon

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Mosser DD. Kotzbauer PT. Sarge KD. Morimoto RI. In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proceedings of the National Academy of Sciences of the United States of America. 87(10):3748-52, 1990. pubmed icon

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Williams GT. Morimoto RI. Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Molecular & Cellular Biology. 10(6):3125-36, 1990. pubmed icon

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Alvares K. Carrillo A. Yuan PM. Kawano H. Morimoto RI. Reddy JK. Identification of cytosolic peroxisome proliferator binding protein as a member of the heat shock protein HSP70 family. Proceedings of the National Academy of Sciences of the United States of America. 87(14):5293-7, 1990. pubmed icon

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Ovsenek N. Williams GT. Morimoto RI. Heikkila JJ. cis-acting sequences and trans-acting factors required for constitutive expression of a microinjected HSP70 gene after the midblastula transition of Xenopus laevis embryogenesis. Developmental Genetics. 11(1):97-109, 1990. pubmed icon

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Milarski KL. Morimoto RI. Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. Journal of Cell Biology. 109(5):1947-62, 1989. pubmed icon

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Williams GT. McClanahan TK. Morimoto RI. E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Molecular & Cellular Biology. 9(6):2574-87, 1989. pubmed icon

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Milarski KL. Welch WJ. Morimoto RI. Cell cycle-dependent association of HSP70 with specific cellular proteins. Journal of Cell Biology. 108(2):413-23, 1989. pubmed icon

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Theodorakis NG. Zand DJ. Kotzbauer PT. Williams GT. Morimoto RI. Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response. Molecular & Cellular Biology. 9(8):3166-73, 1989. pubmed icon

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Theodorakis NG. Banerji SS. Morimoto RI. HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation. Journal of Biological Chemistry. 263(28):14579-85, 1988. pubmed icon

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Schaefer EL. Morimoto RI. Theodorakis NG. Seidenfeld J. Chemical specificity for induction of stress response genes by DNA-damaging drugs in human adenocarcinoma cells. Carcinogenesis. 9(10):1733-8, 1988. pubmed icon

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Mosser DD. Theodorakis NG. Morimoto RI. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Molecular & Cellular Biology. 8(11):4736-44, 1988. pubmed icon

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Ferris DK. Harel-Bellan A. Morimoto RI. Welch WJ. Farrar WL. Frederick, MD.Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 85(11):3850-4, 1988. pubmed icon

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Watowich SS. Morimoto RI. Complex regulation of heat shock- and glucose-responsive genes in human cells. Molecular & Cellular Biology. 8(1):393-405, 1988. pubmed icon

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Banerji SS. Laing K. Morimoto RI. Erythroid lineage-specific expression and inducibility of the major heat shock protein HSP70 during avian embryogenesis. Genes & Development. 1(9):946-53, 1987. pubmed icon

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Harrison GS. Drabkin HA. Kao FT. Hartz J. Hart IM. Chu EH. Wu BJ. Morimoto RI. Chromosomal location of human genes encoding major heat-shock protein HSP70. Somatic Cell & Molecular Genetics. 13(2):119-30, 1987. pubmed icon

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Morgan WD. Williams GT. Morimoto RI. Greene J. Kingston RE. Tjian R. Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Molecular & Cellular Biology. 7(3):1129-38, 1987. pubmed icon

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Theodorakis NG. Morimoto RI. Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Molecular & Cellular Biology. 7(12):4357-68, 1987. pubmed icon

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Moore M. Schaack J. Baim SB. Morimoto RI. Shenk T. Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells. Molecular & Cellular Biology. 7(12):4505-12, 1987. pubmed icon

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Wu BJ. Williams GT. Morimoto RI. Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein. Proceedings of the National Academy of Sciences of the United States of America. 84(8):2203-7, 1987. pubmed icon

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Morimoto RI. Hunt C. Huang SY. Berg KL. Banerji SS. Organization, nucleotide sequence, and transcription of the chicken HSP70 gene. Journal of Biological Chemistry. 261(27):12692-9, 1986. pubmed icon

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Kingston RE. Cowie A. Morimoto RI. Gwinn KA. Binding of polyomavirus large T antigen to the human hsp70 promoter is not required for trans activation. Molecular & Cellular Biology. 6(9):3180-90, 1986. pubmed icon

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Banerji SS. Berg L. Morimoto RI. Transcription and post-transcriptional regulation of avian HSP70 gene expression. Journal of Biological Chemistry. 261(33):15740-5, 1986. pubmed icon

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Wu BJ. Kingston RE. Morimoto RI. Human HSP70 promoter contains at least two distinct regulatory domains. Proceedings of the National Academy of Sciences of the United States of America. 83(3):629-33, 1986. pubmed icon

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Milarski KL. Morimoto RI. Expression of human HSP70 during the synthetic phase of the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 83(24):9517-21, 1986. pubmed icon

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Wu BJ. Hurst HC. Jones NC. Morimoto RI. The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene. Molecular & Cellular Biology. 6(8):2994-9, 1986 . pubmed icon

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Wu BJ. Morimoto RI. Transcription of the human hsp70 gene is induced by serum stimulation. Proceedings of the National Academy of Sciences of the United States of America. 82(18):6070-4, 1985. pubmed icon

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Hunt C. Morimoto RI. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proceedings of the National Academy of Sciences of the United States of America. 82(19):6455-9, 1985. pubmed icon

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Wu B. Hunt C. Morimoto R. Structure and expression of the human gene encoding major heat shock protein HSP70. Molecular & Cellular Biology. 5(2):330-41, 1985. pubmed icon

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Morimoto R. Fodor E. Cell-specific expression of heat shock proteins in chicken reticulocytes and lymphocytes. Journal of Cell Biology. 99:1316-23, 1984. pubmed icon

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Banerji SS. Theodorakis NG. Morimoto RI. Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes. Molecular & Cellular Biology 4:2437-48, 1984. pubmed icon

Transcriptional regulation of heat shock response
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