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McMullen PD, Aprison EZ, Winter PB, Amaral LAN, Morimoto RI, et al. (2012) Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress. PLoS Comput Biol 8(1): e1002338. doi:10.1371/journal.pcbi.1002338

Silva MC, Fox S., Beam M, Thakkar H., Amaral MD and Morimoto RI. A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network. PLOS Genetics 7(12): e1002438. doi:10.1371/journal.pgen.1002438. 2011 Dec 29.

Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, Morimoto RI. Small molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. doi: 10.1038/nchembio.763 2011 Dec 25 [Epub ahead of print].

Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB. ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis. J. Med. Chem. 2011 Dec 22. [Epub ahead of print].

Zhang W, Benmohamed R, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorg Med Chem. 2011 Nov 30. [Epub ahead of print]

Klaic L, Trippier PC, Mishra RK, Morimoto RI, Silverman RB. Remarkable stereospecific conjugate additions to the hsp90 inhibitor celastrol. J Am Chem Soc. 2011 Dec 14;133(49):19634-7. Epub 2011 Nov 21.

Prahlad, V. and Morimoto, R.I. Neuronal Circuitry Regulates the Response of Caenorhabditis Elegans to Misfolded Proteins. Proc Natl Acad Sci USA. 108: 14204-14209 (2011).

Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaça JL, Dias N, Rodrigues P, Oliveira JF, Neves-Carvalho A, Morimoto RI, Maciel P. Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet. 20(15):2996-3009. Epub May 5 (2011).

Gidalevitz T, Prahlad V, Morimoto RI. The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms. Cold Spring Harb Perspect Biol. 2011 May 2. pii: cshperspect.a009704v1. doi: 10.1101/cshperspect.a009704. [Epub ahead of print]

Petre, I., C.L. Hyder, A. Mizera, A. Meinander, A. Mikhailov, R.I. Morimoto, L. Sistonen, J.E. Eriksson, and R-J. Back. A Simple Mass-Action Model for the Eukaryotic Heat Shock Response and its Mathematic Validation. Natural Computing, 10: 595-612, DOI: 10.1007/s11047-010-9216-y (2011)

Xia G, Benmohamed R, Kim J, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. J Med Chem. 2011 Apr 14;54(7):2409-21. Epub 2011 Mar 4.

Morimoto RI, Driessen AJ, Hegde RS, Langer T. The life of proteins: the good, the mostly good and the ugly. Nat Struct Mol Biol. 2011 Jan;18(1):1-4.

Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB. Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorg Med Chem. 2011 Jan 1;19(1):613-22. Epub 2010 Oct 30.

Benmohamed R, Arvanites AC, Kim J, Ferrante RJ, Silverman RB, Morimoto RI, Kirsch DR. Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 Mar;12(2):87-96. Epub 2010 Nov 12.

Kikis EA, Gidalevitz T, Morimoto RI. Protein homeostasis in models of aging and age-related conformational disease. Adv Exp Med Biol. 2010;694:138-59. Review.

Akerfelt, Malin, Morimoto, R.I. and Lea Sistonen. Heat Shock Factors: Integrators of Cell Stress, Development and Lifespan. Nat Rev Mol Cell Biol. 2010 Aug;11(8):545-55. Epub 2010 Jul 14. Review.

McMullen, Patrick D., Morimoto, R.I. and Luis A. Nunes Amaral. Physically Grounded Approach for Estimating Gene Expression from Microarray Data. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13690-5. Epub 2010 Jul 19.

Voisine C, Pedersen JS, Morimoto RI. Chaperone networks: tipping the balance in protein folding diseases. Neurobiol Dis. 2010 Oct;40(1):12-20. Epub 2010 May 21. Review.

Kirstein-Miles, J. and R.I. Morimoto. Caenorhabditis elegans as a Model System to Study Intercompartmental Proteostasis: Interrelation of Mitochondrial Function, Longevity, and Neurodegenerative Diseases. Developomental Dynamics 239: 1529-1538 (2010).

Kirstein-Miles, J. and R.I. Morimoto. Peptides Signal Mitochondrial Stress. Cell Metabolism 11: 177-178 (2010).

Gidalevitz, T., E.A. Kikis, and R.I. Morimoto. A Cellular Perspective on Conformational Disease: The Role of Genetic Background and Proteostasis Networks. Current Opinions in Structural Biology 20: 23-32 (2010).

Ben-Zvi, A., E.- Miller, and R.I. Morimoto. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. PNAS 106(35):14914-14919 (2009).

Powers, E.T., R.I. Morimoto, A. Dillin, J.W. Kelly, and W.E. Balch. Biological and Chemical Approaches to Diseases of Proteostasis Deficiency. Annual Reviews of Biochemistry 78:959-991 (2009).

Sharabi K, Hurwitz A, Simon AJ, Beitel GJ, Morimoto RI, Rechavi G, Sznajder JI, Gruenbaum Y. Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 106(10): 4024-29 (2009).

Gidalevitz, T., T. Krupinski, S. Garcia, and R.I. Morimoto. Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity. PLoS Genet 5(3): e1000399 (2009).

Westerheide, S.D., J. Anckar, S.M. Stevens, Jr., L. Sistonen, and R.I. Morimoto. Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1. Science 20: 1063-1066 (2009).

Prahlad, V., and R.I. Morimoto. Integrating the Stress Response: Lessons for Neurodegenerative Diseases from C. elegans. Trends in Cell Biology 19: 52-61 (2009). PMID: 19112021 [PubMed - as supplied by publisher]

Morimoto R.I. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Review. Genes and Development 22:1427-1438 (2008).

Prahlad, V., T. Cornelius and R.I. Morimoto. Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons. Science 320: 811-814 (2008).

Trott A., J.D. West, L. Klaic, S.D. Westerheide, R.B. Silverman, R.I. Morimoto, and K.A. Morano. Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule. Molecular Biology of the Cell 19: 1104-1112 (2008).

Balch, W.E., R.I. Morimoto, A. Dillin, and J.W. Kelly. Adapting proteostasis for disease intervention. Review. Science 319 (5865): 916-919 (2008).

Garcia, S. M., M.O. Casanueva, M.C. Silva, M.D. Amaral, and R.I. Morimoto. Neuronal signaling modulates protein homeostasis in C. elegans postsynaptic muscle cells. Genes and Development 21: 3006-3016 (2007).

Zourlidou, A. T. Gidalevitz, M. Kristiansen , C. Landles, B. Woodman, D. J. Wells, D. S. Latchman, J. de Belleroche, S. J. Tabrizi, R. I. Morimoto and G. P. Bates. Hsp27 overexpression in the R6/2 mouse model of Huntington’s Disease: Chronic Neurodegeneration does not Induce Hsp27 Activation. Hum. Mol. Genet. Advance Access (2007).

Brignull, H.R., J.F. Morley, and R.I. Morimoto. The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging. (Ed. P. Csermly and L. Vigh) Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks, 594: 167-189, Landes Bioscience (2007).

Finkbeiner, S., A.M. Cuervo, R.I. Morimoto and P.J. Muchowski. Disease-modifiying pathways in neurodegeneration. The Journal of Neuroscience 26(41): 10349-10357 (2006).

Brignull, H.R., J.F. Morley, S.M. Garcia, and R.I. Morimoto. Modeling Polyglutamine Pathogenesis in C. elegans. Methods in Enzymology 412: 256-282 (2006).

Morimoto, R.I. Stress, Aging and Neurodegenerative Disease. The New England Journal of Medicine 355(21): 2254-2255 (2006).

Kitamura, A., H. Kubota, C. Pack, G. Matsumoto, S. Hirayama, Y. Takahashi, H. Kimura., M. Kinjo, R. I. Morimoto and K. Nagata. Cytosolic Chaperonin Prevents Polyglutamine Toxicity with Altering the Aggregation State. Nature Cell Biology 8(10):1163-1175 (2006).

Brignull, H., F. Moore, S. Tang, and R. I. Morimoto. Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal Caenorhabditis elegans Model. The Journal of Neuroscience 26(29): 7597-7606 (2006).

Gidalevitz, T., A. Ben-Zvi, K. Ho, H. Brignull, and R. I. Morimoto. Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases . Science 311: 1471-1474 (2006).

Westerheide, S., T. Kawahara, K. Orton, and R.I. Morimoto. Triptolide, an Inhibitor of the Human Heat Shock Response that Enhances Stress-Induced Cell Death. J. Biol. Chem. 281: 9616-9622 (2006).

Matsumoto, G., S. Kim, and R.I. Morimoto. Huntingtin and mutant SOD1 form aggregate structures with distinct molecular properties in human cells. J Biol Chem. 281: 4477-4485 (2006).

Matsumoto, G., A. Stojanovic, C. Holmberg, S. Kim, and R.I. Morimoto. Structural Properties and Neuronal Toxicity of Amyotrophic Lateral Sclerosis-Associated Cu/Zn Superoxide Dismutase 1 Aggregates. J. Cell Biology 171: 75-85 (2005).

Rieger TR, Morimoto RI, and V. Hatzimanikatis. Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo. Biophys J. 90: 886-95 (2006).

Westerheide, S., and R.I. Morimoto. Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation. J. Biol. Chem. 380: 33097-33100 (2005).

Rieger, T., R.I. Morimoto, and V. Hatzimanikatis. Mathematical Modeling of the Eukaryotic Heat Shock Response: Dynamics of the Hsp70 Promoter. Biophysical Journal 88: 1646-1658 (2005).

Holmberg, C., K. Staniszewski, K. Mensah, A. Chavez, A. Matouschek, and R.I. Morimoto. Inefficient Degradation of Truncated Polyglutamine Proteins by the Proteasome. EMBO Journal 23: 4307-4318 (2004).

Westerheide, S., J. Bosman, B. Mbadugha, T. Kawahara, G. Matsumoto, W. Gu, S. Kim, J. Devlin, R. Silverman, and R.I. Morimoto. Celastrols as Inducers of the Heat Shock Response and Cytoprotection J. Biol. Chem. 279: 56053-60 (2004).

Solomon A, Bandhakavi S, Jabbar S, Shah R, Beitel GJ, Morimoto RI. Caenorhabditis elegans OSR-1 Regulates Behavioral and Physiological Responses to Hyperosmotic Environments. Genetics, 167: 161-170 (2004).

Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A, 101: 6403-6408 (2004).

Mosser DD, Morimoto RI. Molecular chaperones and the stress of oncogenesis. Oncogene, 23(16):2907-18 (2004).

Morley, J.F. and Morimoto, R. Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones. Mol Biol Cell. Feb;15:657-64 (2004).

Colon-Ramos DA, Irusta PM, Gan EC, Olson MR, Song J, Morimoto RI, Elliott RM, Lombard M, Hollingsworth R, Hardwick JM, Smith GK, Kornbluth S. Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Mol Biol Cell. Oct;14:4162-72 (2003).

Soojin Kim, Ellen A. A. Nollen, Kazunori Kitagawa, Vytautas P. Bindokas and Richard I. Morimoto. Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4: 826-831 (2002).

Morimoto, R.I. Dynamic Remodeling of Transcription Complexes by Molecular Chaperones. Cell 110: 1–20 (2002).

Morley J.F., Brignull H.R., Weyers J.J., Morimoto R.I. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. (2002).

Nollen EA, Morimoto RI. Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J Cell Sci. 115: 2809-16 (2002).

Jolly, C., L. Konecny, D.L. Grady, Y.A. Kutskova, J.J. Cotto, R.I. Morimoto, and C. Vourch. In vivo Binding of Active HSF1 to Human Chromosome 9 Heterochromatin During Stress. J. Cell Biology 156: 775-781 (2002).

Nollen, E.A.A. and R.I. Morimoto. Cellular and Molecular Response to Stress, Misfolded Proteins, and Diseases of Protein Misfolding (ed. T. Creighton), Encyclopedia of Molecular Medicine, p. 1553-1563, Wiley Press (2002).

Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107:893-903 (2001).

Tai LJ, McFall SM, Huang K, Demeler B, Fox SG, Brubaker K, Radhakrishnan I, Morimoto RI. Structure-function analysis of the heat shock factor binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. J Biol Chem. (2001).

Mathew A, Mathur SK, Jolly C, Fox SG, Kim S, Morimoto RI. Stress-specific activation and repression of heat shock factors 1 and 2. Mol Cell Biol. 21: 7163-71 (2001).

Ahn SG, Liu PC, Klyachko K, Morimoto RI, Thiele DJ. The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress. Genes Dev.15: 2134-45 (2001).

Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20: 3800-10 (2001).

Carr, Menco, Yankova, Morimoto, and Farbman. Odorants as Cell-Type Specific Activators of a Heat Shock Response in the Rat Olfactory Mucosa. Journal of Comparative Neurology 432: 425-439 (2001).

Thress K, Song J, Morimoto RI, Kornbluth S. Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. EMBO J 1:1033-1041 (2001).

Song, J, Takeda M and Morimoto RI. Hsp70-Bag1 complex mediates a physiological stress signaling pathway that regulates Raf-1/ERK and cell growth. Nature Cell Biology 3: 276-282 (2001).

Jolly C and Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. Journal of the National Cancer Institute 92:1564-1572, 2000.

Mosser, D., Caron, A.W., Bourget, L., Meriin, A.B., Sherman, M.Y., Morimoto, R.I., and Massie, B. The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis. Molecular and Cellular Biology 20: 7146-7159 (2000).

Beere H, Wolf B, Mosser R, Klein K, Kuwana T, Morimoto R, Cohen G and Green D Heat shock protein 70 (Hsp70) inhibits apoptosis by preventing recruitment of procaspase-9 to aggregated Apaf-1. Nature Cell Bio. 2; 469-475, 2000.

Satyal SH, Schmidt E, Kitagawa K, Sondheimer N, Lindquist S, Kramer JM, Morimoto RI. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci U S A 23;97(11):5750-5, 2000.

Freeman BC, Michels A, Son, J, Kampinga H and Morimoto RI Analysis of molecular chaperone activities using in vitro and in vivo approaches. Methods in Molecular Biology, (ed. S. Keyse), p. 393-419, Humana Press, 2000.

Mathew A, Shi Y, Jolly C, Morimoto RI. Analysis of the mammalian heat-shock response. Inducible gene expression and heat-shock factor activity. Methods Mol Biol 2000.

Nollen EA. Brunsting JF. Song J. Kampinga HH. Morimoto RI. Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol:20(3):1083-8, 2000.

Carr VM, Morimoto RI, and Farbman AI. Development and further characterization of a small subclass of rat olfactory receptor neurons that shows immunoreactivity for the HSP70 heat shock protein. J Comp Neurol., 404:375-86, 1999.

Super HJ. Hasenkrug KJ. Simmons S. Brooks DM. Konzek R. Sarge KD. Morimoto RI. Jenkins NA. Gilbert DJ. Copeland NG. Frankel W. Chesebro B. Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15. J Virol:73(9):7848-52, 1999.

Cotto JJ and Morimoto RI. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors [Review]. Biochem. Soc. Symp., 64:105-118, 1999.

Montgomery DL, Morimoto RI, Gierasch LM Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling. J Mol Biol:286(3):915-32, 1999.

Morimoto RI. The Heat Shock Response: Regulation and Function of Molecular Chaperones. The Encyclopedia of Molecular Biology (ed. T. Creighton), p.1088-1098, Wiley Press, 1999.

Jolly C. Morimoto RI. Stress and the cell nucleus: dynamics of gene expression and structure reorganization. Gene Expr:7(4-6):261-70, 1999.

Wang SM. Khandekar JD. Kaul KL. Winchester DJ. Morimoto RI. A method for the quantitative analysis of human heat shock gene expression using a multiplex RT-PCR assay. Cell Stress & Chaperones.

Jolly C. Vourc'h C. Robert-Nicoud M. Morimoto RI. Intron-independent association of splicing factors with active genes. Journal of Cell Biology. 14;145(6):1133-43, 1999.

Jolly C. Usson Y. Morimoto RI. Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc National Academy of Science USA. 8;96(12):6769-74, 1999.

Osipiuk J, Walsh MA, Freeman BC, Morimoto, RI, Joachimiak, A Structure of a new crystal form of human Hsp70 ATPase domain Acta Crystallographica, D55, 1105-1107, 1999.

Melville MW. Tan SL. Wambach M. Song J. Morimoto RI. Katze MG. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. Journal of Biological Chemistry. 5;274(6):3797-803, 1999 .

Morimoto, RI. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. (Review) Genes & Development, 12:3788-3796, 1998.

Satyal, SH and Morimoto, R. I Biochemical events in the activation and attenuation of the heat shock transcriptional response. J. Biosci. 23: 303-311, 1998.

Bimston D, Song J, Winchester D, Takayama S, Reed JC, Morimoto RI BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from sugstrate release EMBO 17: 6871-6878, 1998.

Furukawa M, Uchiumi T, Nomoto M, Takano H, Morimoto RI, Naito S, Kuwano M, Kohno K The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIalpha gene by heat shock. J Biol Chem 1998.

Morimoto RI, Santoro MG Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection Nat Biotechnol 1998 Sep;16(9):833-8.

Mathew A and Morimoto, RI. Role of the heat-shock response in the life and death of proteins. Ann NY Acad Sci., 851:99-111, 1998.

Mathew A, Mathur SK, Morimoto RI Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin- proteasome pathway Mol Cell Biol:18(9):5091-8, 1998.

Tanabe M, Kawazoe Y, Takeda S, Morimoto RI, Nagata K, Nakai A Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. EMBO J 1998 Mar 16;17(6):1750-8.

Shi Y, Mosser DD, Morimoto RI Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev., 12(5):654-66, 1998.

Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI Negative regulation of the heat shock transcriptional response by HSBP1. Genes Dev 1998 Jul 1;12(13):1962-7.

Jolly C. Morimoto R. Robert-Nicoud M. Vourc'h C . HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites. Journal of Cell Science. 110 ( Pt 23):2935-41, 1997.

Cotto J. Fox S. Morimoto R . HSF1 granules: a novel stress-induced nuclear compartment of human cells. Journal of Cell Science. 110 ( Pt 23):2925-34, 1997.

Morimoto RI, Kline, MP, Bimston DN and Cotto, JJ. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochm., 32:17-29, 1997.

Kline MP. Morimoto RI . Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Molecular & Cellular Biology. 17(4):2107-15, 1997.

Rallu M. Loones M. Lallemand Y. Morimoto R. Morange M. Mezger V . Function and regulation of heat shock factor 2 during mouse embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 94(6):2392-7, 1997.

Takayama S. Bimston DN. Matsuzawa S. Freeman BC. Aime-Sempe C. Xie Z. Morimoto RI. Reed JC . BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO Journal. 16(16):4887-96, 1997.

Kimura Y. Rutherford SL. Miyata Y. Yahara I. Freeman BC. Yue L. Morimoto RI. Lindquist S . Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes & Development. 11(14):1775-85, 1997.

Kanei-Ishii C. Tanikawa J. Nakai A. Morimoto RI. Ishii S . Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science. 277(5323):246-8, 1997.

Sriram M. Osipiuk J. Freeman B. Morimoto R. Joachimiak A . Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain. Structure. 5(3):403-14, 1997.

Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI and Nagata K. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol 17:469-81, 1997.

Freeman BC. Toft DO. Morimoto RI . Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein P23. Science 274:1718-1720, 1996.

Hansen S, Midgley CA, Lane DP, Freeman BC, Morimoto RI and Hupp TR. Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70. J Biol. Chem., 271: 30922-8, 1996.

Morimoto RI. Kroeger PE. Cotto JJ . The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions. [Review] [116 refs] EXS. 77:139-63, 1996.

Freeman BC. Morimoto RI . The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. EMBO Journal. 15(12):2969-79, 1996.

Cotto JJ. Kline M. Morimoto RI . Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. Journal of Biological Chemistry. 271(7):3355-8, 1996.

Marcuccilli CJ. Mathur SK. Morimoto RI. Miller RJ. Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock. Journal of Neuroscience. 16(2):478-85, 1996.

Nakai A. Kawazoe Y. Tanabe M. Nagata K. Morimoto RI. The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Molecular & Cellular Biology. 15(10):5268-78, 1995.

Freeman BC. Myers MP. Schumacher R. Morimoto RI. Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO Journal. 14(10):2281-92, 1995.

Bhattacharyya T. Karnezis AN. Murphy SP. Hoang T. Freeman BC. Phillips B. Morimoto RI. Cloning and subcellular localization of human mitochondrial hsp70. Journal of Biological Chemistry. 270(4):1705-10, 1995.

Shi Y, Kroeger PE and Morimoto RI. The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive. Mol. Cell Biol., 15:4309-4318, 1995.

Lee BS. Chen J. Angelidis C. Jurivich DA. Morimoto RI. Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage. PNAS 92(16):7207-11, 1995.

Carr VM. Murphy SP. Morimoto RI. Farbman AI. Small subclass of rat olfactory neurons with specific bulbar projections is reactive with monoclonal antibodies to the HSP70 heat shock protein. Journal of Comparative Neurology. 348(1):150-60, 1994.

Kroeger PE. Morimoto RI. Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity. Molecular & Cellular Biology. 14(11):7592-603, 1994.

Jurivich DA. Sistonen L. Sarge KD. Morimoto RI. Arachidonate is a potent modulator of human heat shock gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 91(6):2280-4, 1994.

Sistonen L. Sarge KD. Morimoto RI. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Molecular & Cellular Biology. 14(3):2087-99, 1994.

Kanei-Ishii C. Yasukawa T. Morimoto RI. Ishii S. c-Myb-induced trans-activation mediated by heat shock elements without sequence-specific DNA binding of c-Myb. Journal of Biological Chemistry. 269(22):15768-75, 1994.

Sarge KD. Park-Sarge OK. Kirby JD. Mayo KE. Morimoto RI. Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biology of Reproduction. 50(6):1334-43, 1994.

Fawcett TW. Sylvester SL. Sarge KD. Morimoto RI. Holbrook NJ. Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. Journal of Biological Chemistry. 269(51):32272-8, 1994.

Mezger V. Rallu M. Morimoto RI. Morange M. Renard JP. Heat shock factor 2-like activity in mouse blastocysts. Developmental Biology. 166(2):819-22, 1994.

Mathur SK. Sistonen L. Brown IR. Murphy SP. Sarge KD. Morimoto RI. Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 91(18):8695-9, 1994.

Li WW. Sistonen L. Morimoto RI. Lee AS. Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element. Molecular & Cellular Biology. 14(8):5533-46, 1994.

Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. [Review] Science. 259(5100):1409-10, 1993.

Sarge KD. Murphy SP. Morimoto RI. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress [published errata appear in Mol Cell Biol 1993 May;13(5):3122-3 and 1993 Jun;13(6):3838-9]. Molecular & Cellular Biology. 13(3):1392-407, 1993.

Kroeger PE. Sarge KD. Morimoto RI. Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element. Molecular & Cellular Biology. 13(6):3370-83, 1993.

Beere HM. Morimoto RI. Hickman JA. Investigations of mechanisms of drug-induced changes in gene expression: N-methylformamide-induced changes in synthesis of the M(r) 72,000 constitutive heat shock protein during commitment of HL-60 cells to granulocyte differentiation. Cancer Research. 53(13):3034-9, 1993.

Nakai A. Morimoto RI. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Molecular & Cellular Biology. 13(4):1983-97, 1993.

Sistonen L. Sarge KD. Phillips B. Abravaya K. Morimoto RI. Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Molecular & Cellular Biology. 12(9):4104-11, 1992.

Morimoto RI. Sarge KD. Abravaya K. Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses. [Review] Journal of Biological Chemistry. 267(31):21987-90, 1992.

Jurivich DA. Sistonen L. Kroes RA. Morimoto RI. Effect of sodium salicylate on the human heat shock response. Science. 255(5049):1243-5, 1992.

Morimoto RI. Transcription factors: positive and negative regulators of cell growth and disease. [Review] Current Opinion in Cell Biology. 4(3):480-7, 1992 .

Amici C. Sistonen L. Santoro MG. Morimoto RI. Antiproliferative prostaglandins activate heat shock transcription factor.Proceedings of the National Academy of Sciences of the United States of America. 89(14):6227-31, 1992.

Abravaya K. Myers MP. Murphy SP. Morimoto RI. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes & Development. 6(7):1153-64, 1992.

Sarge KD. Zimarino V. Holm K. Wu C. Morimoto RI. Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes & Development. 5(10):1902-11, 1991.

Abravaya K. Phillips B. Morimoto RI. Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes & Development. 5(11):2117-27, 1991.

Phillips B. Abravaya K. Morimoto RI. Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses. Journal of Virology. 65(11):5680-92, 1991.

Kroes RA. Abravaya K. Seidenfeld J. Morimoto RI. Selective activation of human heat shock gene transcription by nitrosourea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 88(11):4825-9, 1991.

Watowich SS. Morimoto RI. Lamb RA. Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene. Journal of Virology. 65(7):3590-7, 1991.

Abravaya K. Phillips B. Morimoto RI. Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting. Molecular & Cellular Biology. 11(1):586-92, 1991.

Koskinen PJ. Sistonen L. Evan G. Morimoto R. Alitalo K. Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells. Journal of Virology. 65(2):842-51, 1991.

Morimoto RI. Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation. [Review] Cancer Cells. 3(8):295-301, 1991.

Phillips B. Morimoto RI. Transcriptional regulation of human hsp70 genes: relationship between cell growth, differentiation, virus infection, and the stress response. Results & Problems in Cell Differentiation. 17:167-87, 1991.

Sarge KD. Morimoto RI. Surprising features of transcriptional regulation of heat shock genes. [Review] Gene Expression. 1(3):169-73, 1991.

Mosser DD. Kotzbauer PT. Sarge KD. Morimoto RI. In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proceedings of the National Academy of Sciences of the United States of America. 87(10):3748-52, 1990.

Williams GT. Morimoto RI. Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Molecular & Cellular Biology. 10(6):3125-36, 1990.

Alvares K. Carrillo A. Yuan PM. Kawano H. Morimoto RI. Reddy JK. Identification of cytosolic peroxisome proliferator binding protein as a member of the heat shock protein HSP70 family. Proceedings of the National Academy of Sciences of the United States of America. 87(14):5293-7, 1990.

Ovsenek N. Williams GT. Morimoto RI. Heikkila JJ. cis-acting sequences and trans-acting factors required for constitutive expression of a microinjected HSP70 gene after the midblastula transition of Xenopus laevis embryogenesis. Developmental Genetics. 11(1):97-109, 1990.

Milarski KL. Morimoto RI. Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. Journal of Cell Biology. 109(5):1947-62, 1989.

Williams GT. McClanahan TK. Morimoto RI. E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Molecular & Cellular Biology. 9(6):2574-87, 1989.

Milarski KL. Welch WJ. Morimoto RI. Cell cycle-dependent association of HSP70 with specific cellular proteins. Journal of Cell Biology. 108(2):413-23, 1989.

Theodorakis NG. Zand DJ. Kotzbauer PT. Williams GT. Morimoto RI. Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response. Molecular & Cellular Biology. 9(8):3166-73, 1989.

Theodorakis NG. Banerji SS. Morimoto RI. HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation. Journal of Biological Chemistry. 263(28):14579-85, 1988.

Schaefer EL. Morimoto RI. Theodorakis NG. Seidenfeld J. Chemical specificity for induction of stress response genes by DNA-damaging drugs in human adenocarcinoma cells. Carcinogenesis. 9(10):1733-8, 1988.

Mosser DD. Theodorakis NG. Morimoto RI. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Molecular & Cellular Biology. 8(11):4736-44, 1988.

Ferris DK. Harel-Bellan A. Morimoto RI. Welch WJ. Farrar WL. Frederick, MD.Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 85(11):3850-4, 1988.

Watowich SS. Morimoto RI. Complex regulation of heat shock- and glucose-responsive genes in human cells. Molecular & Cellular Biology. 8(1):393-405, 1988.

Banerji SS. Laing K. Morimoto RI. Erythroid lineage-specific expression and inducibility of the major heat shock protein HSP70 during avian embryogenesis. Genes & Development. 1(9):946-53, 1987.

Harrison GS. Drabkin HA. Kao FT. Hartz J. Hart IM. Chu EH. Wu BJ. Morimoto RI. Chromosomal location of human genes encoding major heat-shock protein HSP70. Somatic Cell & Molecular Genetics. 13(2):119-30, 1987.

Morgan WD. Williams GT. Morimoto RI. Greene J. Kingston RE. Tjian R. Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Molecular & Cellular Biology. 7(3):1129-38, 1987.

Theodorakis NG. Morimoto RI. Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Molecular & Cellular Biology. 7(12):4357-68, 1987.

Moore M. Schaack J. Baim SB. Morimoto RI. Shenk T. Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells. Molecular & Cellular Biology. 7(12):4505-12, 1987.

Wu BJ. Williams GT. Morimoto RI. Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein. Proceedings of the National Academy of Sciences of the United States of America. 84(8):2203-7, 1987.

Morimoto RI. Hunt C. Huang SY. Berg KL. Banerji SS. Organization, nucleotide sequence, and transcription of the chicken HSP70 gene. Journal of Biological Chemistry. 261(27):12692-9, 1986.

Kingston RE. Cowie A. Morimoto RI. Gwinn KA. Binding of polyomavirus large T antigen to the human hsp70 promoter is not required for trans activation. Molecular & Cellular Biology. 6(9):3180-90, 1986.

Banerji SS. Berg L. Morimoto RI. Transcription and post-transcriptional regulation of avian HSP70 gene expression. Journal of Biological Chemistry. 261(33):15740-5, 1986.

Wu BJ. Kingston RE. Morimoto RI. Human HSP70 promoter contains at least two distinct regulatory domains. Proceedings of the National Academy of Sciences of the United States of America. 83(3):629-33, 1986.

Milarski KL. Morimoto RI. Expression of human HSP70 during the synthetic phase of the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 83(24):9517-21, 1986.

Wu BJ. Hurst HC. Jones NC. Morimoto RI. The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene. Molecular & Cellular Biology. 6(8):2994-9, 1986 .

Wu BJ. Morimoto RI. Transcription of the human hsp70 gene is induced by serum stimulation. Proceedings of the National Academy of Sciences of the United States of America. 82(18):6070-4, 1985.

Hunt C. Morimoto RI. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proceedings of the National Academy of Sciences of the United States of America. 82(19):6455-9, 1985.

Wu B. Hunt C. Morimoto R. Structure and expression of the human gene encoding major heat shock protein HSP70. Molecular & Cellular Biology. 5(2):330-41, 1985.

Morimoto R. Fodor E. Cell-specific expression of heat shock proteins in chicken reticulocytes and lymphocytes. Journal of Cell Biology. 99:1316-23, 1984.

Banerji SS. Theodorakis NG. Morimoto RI. Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes. Molecular & Cellular Biology 4:2437-48, 1984.