The Pinkett Lab is exploring the molecular basis for transport, a cellular process that is universally conserved.  ATP Binding Cassette (ABC) transporter proteins are major agents of multidrug resistance (MDR) in bacteria and humans. These membrane proteins harvest the energy of ATP hydrolysis to transport a vast range of molecules across cell membranes and act to protect cells from cytotoxic and antimicrobial agents. 


In order to determine the mechanisms underlying transport and its regulation, the lab uses a combination of x-ray crystallography and biochemistry and biophysics.


   


    

Department of Molecular Biosciences

Northwestern University

Pinkett

Lab

Collaborations


“Detection of Multidrug Resistant Proteins using Plasmonic Nanomechanical Sensors”

Collaboration with the Balogun lab in McCormick

iCET Award

http://icet.northwestern.edu


“Spatiotemporal control of Protein Function: Ligand activation of TEV Protease”

Collaboration with Shuman lab at U of Chicago

CBC Catalyst Award

www.chicagobiomedicalconsortium.org