Selected Publications from the Carthew Lab



  3. 2011                                                                                                                      


  5. Biological robustness and the role of microRNAs: a network perspective.

  6. Pelaez, N., and R.W. Carthew 

  7. Curr. Topics Dev. Biol. in press (2011)


  9. Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing.

  10. Harris, D.A., Kim, K., Nakahara, K., Vazquez-Doorman, C. and R.W. Carthew

  11. J. Cell Biol. 194, 77-87 (2011)


  13. Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model.

  14. Gemp, I., Carthew, R.W. and S. Hilgenfeldt 

  15. PLOS Comp. Biol. 7, e1002115 (2011)



  18. 2010                                                                                                                       


  20. Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila.

  21. Marques, J.T., Kim, K., Wu, P-H., Alleyne, T., Jafari, N. and R.W. Carthew

  22. Nature Struct. Mol. Biol. 17, 24-30 (2010)


  24. Evolutionary flux of canonical microRNAs and mirtrons in Drosophila.

  25. Lu, J., Shen, Y., Carthew, R.W., Wang, S.M. and C.I. Wu

  26. Nature Genetics 42, 9–10 (2010)



  29. 2009                                                                                                                      


  31. The endo-siRNA pathway is required for robust development of the Drosophila embryo.

  32. Lucchetta, E.M., Carthew, R.W. and R.F. Ismagilov

  33. PLOS One 4, e7576 (2009)


  35. A microRNA imparts robustness against environmental fluctuation during development.

  36. Li, X., Cassidy, J., Reinke, C.A., Fischboeck, S. and R.W. Carthew

  37. Cell 137, 273-282 (2009)


  39. Silencing by small RNAs is linked to endosomal trafficking.

  40. Lee, Y.S., Pressman, S., Andress, A.P., Kim, K.,, White, J.L., Cassidy, J.J., Li, X., Lubell, K., Lim, D.H., Cho, I.S., Nakahara, K., Preall, J.B., Bellare, P., Sontheimer, E.J. and R.W. Carthew 

  41. Nature Cell Biol. 11, 1150-1156 (2009)


  43. Origins and mechanisms of miRNAs and siRNAs.

  44. Carthew, R.W. and E.J. Sontheimer

  45. Cell 136, 642-655 (2009)



  48. 2008                                                                                                                       


  50. Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye.

  51. Zheng, L and R.W. Carthew

  52. Mech. Dev. 125, 18-29 (2008)


  54. BMP signaling goes post-transcriptional in a microRNA-sort of way. 

  55. Reinke, C.A. and R.W. Carthew 

  56. Dev. Cell 15, 174-175 (2008)


  58. The birth and death of microRNA genes in Drosophila.

  59. Lu, J., Shen, Y., Wu, Q., Kumar, S., He, B., Carthew, R.W., Wang, S. and C.I. Wu 

  60. Nature Genetics 40, 351-355 (2008)


  62. Adaptive evolution of newly-emerged microRNA genes in Drosophila.

  63. Lu, J., Fu, Y., Kumar, S., Shen, Y., Zeng, K., Carthew, R.W. and C.I. Wu

  64. Mol. Biol. Evol. 25, 929-938 (2008)


  66. Functional analysis of Dicer-2 missense mutations in the siRNA pathway of Drosophila.

  67. Lim, D-W., Kim, J., Kim, S., Carthew, R.W. and Y.S. Lee 

  68. Biochim. Biophys. Res. Comm. 37, 525-530 (2008)


  70. Physical modeling of cell geometric order in an epithelial tissue.

  71. Hilgenfeldt, S., Erisken, S. and R.W. Carthew

  72. Proc. Nat. Acad. Sci. USA 105, 907-911 (2008)


  74. Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye.

  75. Hayashi, T., Xu, C. and R.W. Carthew

  76. Development 135, 2787-2796 (2008)



  79. 2007                                                                                                                       


  81. Post transcriptional gene silencing.

  82. Pressman, S., Bei, Y and R.W. Carthew

  83. Cell 130, 570 (2007)


  85. A call to arms: co-evolution of animal viruses and host innate immune responses.

  86. Marques J.T. and R.W. Carthew

  87. Trends Genetics 23, 359-364 (2007)


  89. Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes.

  90. Kim K., Lee, Y.S. and R.W. Carthew

  91. RNA 13, 22-29 (2007)


  93. Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina.

  94. Käfer, J., Hayashi, T., Marée, A.F.M., Carthew, R.W. and F. Graner

  95. Proc. Nat. Acad. Sci. USA 104, 18549-18554 (2007)


  97. Pattern formation in the Drosophila eye.

  98. Carthew R.W.

  99. Curr. Opin. Genet. Dev. 17, 309-313 (2007)


  101. Small RNA-mediated epigenetic modifications.

  102. Bei, Y., Pressman, S. and R.W. Carthew

  103. Cell 130, 665 (2007)



  106. 2006                                                                                                                       


  108. RNA interference directs innate immunity against viruses in adult Drosophila.

  109. Wang X-H., Aliyari R., Li W-X., Li H-W., Kim K., Carthew R.W., Atkinson P. and X-W. Ding

  110. Science 312, 452-454 (2006)


  112. The RNAi Pathway Initiated by Dicer-2 in Drosophila.

  113. Kim K., Lee Y.S., Harris D., Nakahara K. and R.W. Carthew

  114. Cold Spring Harbor Symp. Quant. Biol. 71, 39-44 (2006)


  116. Gene regulation by microRNAs.

  117. Carthew R.W.

  118. Curr. Opin. Genet. Dev. 16, 203-208 (2006)


  120. A new RNA dimension to genome control.

  121. Carthew R.W. 

  122. Science 313, 305-306 (2006)


  124. Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo.

  125. Bayraktar J, Zygmunt D. and R.W. Carthew 

  126. J Cell Sci. 119, 711-721 (2006)



  129. 2005                                                                                                                       


  131. Functional roles of endogenous miRNAs and siRNAs.

  132. Sontheimer E.J. and R.W. Carthew

  133. Cell 122, 9-12 (2005)


  135. Targets of microRNA regulation in the Drosophila oocyte proteome.

  136. Nakahara K., Kim K., Sciulli C., Dowd S.R., Minden J.S. and R.W. Carthew

  137. Proc. Nat. Acad. Sci. USA 102, 12023-12028 (2005)


  139. A miRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye.

  140. Li X. and R.W. Carthew

  141. Cell 123, 1267-1277 (2005)


  143. Stem cell division is regulated by the microRNA pathway.

  144. Hatfield S.D., Shcherbata H.R., Fischer K.A., Nakahara K., Carthew R.W. and H. Ruohola-Baker.

  145. Nature 435, 974-978 (2005)


  147. Adhesion proteins and control of cell shape.

  148. Carthew R.W.

  149. Curr. Opin. Genet. Dev. 15, 358-363 (2005)



  152. 2004                                                                                                                       


  154. Argonaute Journeys into the Heart of RISC.

  155. Sontheimer E.J. and R.W. Carthew

  156. Science 305, 1409-1410 (2004)


  158. A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila.

  159. Pham J.W., Pellino J.L., Lee Y.S., Carthew R.W. and E.J. Sontheimer 

  160. Cell 117, 83-94 (2004)


  162. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.

  163. Lee Y.S., Nakahara K., Pham J.W., Kim K., He Z., Sontheimer E.J. and R.W. Carthew 

  164. Cell 117, 69-81 (2004)


  166. Surface mechanics mediate pattern formation in the developing retina.

  167. Hayashi T. and R.W. Carthew

  168. Nature 431, 647-652 (2004)


  170. Genome wide survey of protein kinases required for cell cycle progression.

  171. Bettencourt-Dias M., Giet R., Sinka R., Mazumdar A., Lock W.G., Balloux F., Zafiropoulos P.J., Yamaguchi S., Winter S., Carthew R.W., Cooper M., Jones D., Frenz L. and D.M. Glover

  172. Nature 432, 980-987 (2004)



  175. 2003                                                                                                                       


  177. Chibby, a nuclear ß-catenin-associated antagonist of the Wnt/Wingless pathway.

  178. Takemaru K-I., Yamaguchi S., Lee Y.S., Zhang Y., Carthew R.W. and R.T. Moon

  179. Nature 422, 905-909 (2003)


  181. Making a better RNAi vector for Drosophila: Use of Intron Spacers.

  182. Lee Y.S. and R.W. Carthew

  183. Methods 30, 322-329 (2003)



  186. 2002                                                                                                                       


  188. Phyllopod acts as an adaptor protein to link the Sina ubiquitin ligase to the substrate protein Tramtrack.

  189. Li S., Xu C. and R.W. Carthew

  190. Mol. Cell. Biol. 22, 6854-6865 (2002)


  192. RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E.

  193. Kennerdell J.R., Yamaguchi S. and R.W. Carthew

  194. Genes Dev. 16, 1884-1889 (2002)



  197. 2000                                                                                                                       


  199. Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye.

  200. Xu C., Kauffmann R.C., Zhang J., Kladny S. and R.W. Carthew

  201. Cell 103, 87-97 (2000)


  203. Heritable gene silencing in Drosophila using double-stranded RNA.

  204. Kennerdell J.R. and R.W. Carthew

  205. Nature Biotechnology 18, 896-898 (2000)



  208. 1999                                                                                                                       


  210. Ebi regulates epidermal growth factor receptor signaling pathways in Drosophila.

  211. Dong X., Tsuda L., Zavitz K.H., Lin M., Li S., Carthew R.W. and S.L. Zipursky

  212. Genes Dev. 13, 954-965 (1999)



  215. 1998                                                                                                                       


  217. Interactions between Wingless and DFz2 during Drosophila wing development.

  218. Zhang J. and R.W. Carthew

  219. Development 125, 3075-3085 (1998)


  221. Proteasomal regulation of nuclear receptor corepressor-mediated repression.

  222. Zhang J., Guenther M.G., Carthew R.W. and M.A. Lazar

  223. Genes Dev. 12, 1775-1780 (1998)


  225. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled2 act in the Wingless pathway.

  226. Kennerdell, J.R. and R.W. Carthew

  227. Cell 95, 1017-1026 (1998)



  230. 1997                                                                                                                       


  232. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack.

  233. Li S., Li Y., Carthew R.W. and Z.-C. Lai

  234. Cell 90, 469-478 (1997)



  237. 1996                                                                                                                       


  239. Ras1 signaling and transcriptional competence in the R7 cell of Drosophila.

  240. Kauffmann R.C., Li S., Gallagher P.A., Zhang J. and R.W. Carthew

  241. Genes Dev. 10, 2167-2178 (1996)



  244. 1995                                                                                                                       


  246. Frizzled regulates mirror-symmetric pattern formation in the Drosophila eye.

  247. Zheng L., Zhang J. and R.W. Carthew

  248. Development 121, 3045-3055 (1995)


  250. Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.

  251. Kauffmann R.C., Qian, Y., Vogt, A., Sebti, S.M., Hamilton, A.D. and R.W. Carthew

  252. Proc. Nat. Acad. Sci. USA 92, 10919-10923 (1995)



  255. 1994                                                                                                                       


  257. Identification of genes that interact with the sina gene in Drosophila eye development.

  258. Carthew, R.W., Neufeld, T. and G.M. Rubin

  259. Proc. Nat. Acad. Sci. USA 91, 11689-11693 (1994)






Carthew Lab Publications

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