Our lab demonstrated that Measles virus can inhibit cytokine responses by direct interference with host STAT protein-dependent signaling systems. Expression of the Measles V protein prevents both IFN- a / b and IFN- g induced transcriptional responses and inhibits STAT3-dependent signaling via IL-6 or v-Src.   While Measles V protein associates with cellular STAT1, STAT2, STAT3, and IRF9, as well as several unidentified partners, it does not interfere with STAT1 or STAT2 tyrosine phosphorylation, yet effectively prevents IFN-induced STAT nuclear translocation.

Publications:

Parisien JP, Horvath CM. (2013) Detection of Activated STAT Proteins.
Methods Mol Biol, 2013;967:135-45

Parisien JP, Bamming D, Komuro A, Ramachandran A, Rodriguez JJ, Barber G, Wojahn RD, Horvath CM. (2009) A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2.
J Virol. Jul;83(14):7252-60.

Ramachandran A, Parisien JP, Horvath CM (2008) STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition.
Virol. Sep;82(17):8330-8.

Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM.
(2006) Measles virus V protein inhibits p53 family member p73.
J Virol. Jun;80(11):5644-50.

Ulane CM, Kentsis A, Cruz CD, Parisien JP, Schneider KL, Horvath CM.
(2005) Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. J Virol. Aug;79(16):10180-9.

Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM (2003)
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein J Virol. Jul;77(13):7635-44.

Ulane CM, Rodriguez JJ, Parisien JP, Horvath CM.(2003) STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling.
J Virol. Jun;77(11):6385-93.

Kraus TA, Lau JF, Parisien JP, Horvath CM.(2003) A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response.
J Biol Chem. Apr 11;278(15):13033-8.

Rodriguez JJ, Parisien JP, Horvath CM (2002) Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation. J Virol. Nov;76(22):11476-83.

Parisien JP, Lau JF, Horvath CM. (2002) STAT2 acts as a host range determinant for species-specific paramyxovirus interferon antagonism and simian virus 5 replication. J Virol. Jul;76(13):6435-41.

Parisien JP, Lau JF, Rodriguez JJ, Ulane CM, Horvath CM. (2002) Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction.
J Virol. May;76(9):4190-8.

Salvatore M, Basler CF, Parisien JP, Horvath CM, Bourmakina S, Zheng H, Muster T, Palese P, García-Sastre A. (2002) Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis. J Virol. Feb;76(3):1206-12.

Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK.(2001) TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem. Dec 21;276(51):47771-4.

Parisien JP, Lau JF, Rodriguez JJ, Sullivan BM, Moscona A, Parks GD, Lamb RA, Horvath CM. (2001) The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2. Virology. May 10;283(2):230-9.

Lau JF, Parisien JP, Horvath CM.(2000) Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors.
Proc Natl Acad Sci U S A. Jun 20;97(13):7278-83.