About the Group
The Rosenzweig group is focused on understanding metalloprotein function on the molecular level. We use X-ray crystallographic, spectroscopic, biochemical, genetic, and bioinformatic approaches to attack problems at the forefront of bioinorganic chemistry. Projects in the laboratory are divided into two areas, metalloenzymes and metal homeostasis, with an increasing focus on integral membrane proteins. Specific areas of interest include biological methane oxidation, metal uptake and transport, and oxygen activation by metalloenzymes.
Our collaborative paper with LLNL is published in Nat. Commun. Read the article.
Tom and Amy's Perspective on MCR is published in Science. Read the article.
Grace and Monica's paper on copper-responsive gene regulation in Ms. trichosporium OB3b is published in Metallomics. Read the article.
Tom, Grace, and Joe's paper on CopC is published in Biochemistry. Read the article.
Our collaborative paper with the Statsyuk group is published in JACS. Read the article.
Aaron's article on a novel metal binding domain from a P1B-4-ATPase is published in Nature Chem Biol. Read the article.
Oriana Fisher has joined the group as a postdoctoral fellow. Oriana received her Ph. D. from Yale working with Prof. Titus Boggon.
Congratulations to our graduating seniors Joe, Monica, Caleb, and Madeline!
Sarah's Current Topic article is published in Biochemistry. Read the article.
Amy's News & Views commentary on sMMO is published in Nature. Read the article.
Aaron, Grace, and Joe presented their research at the Bioinorganic Chemistry GRS chaired by Tom.
Sarah has left us for a position at Abbott Laboratories. Congratulations and good luck!
Joe received a Fletcher Prize for Undergraduate Research for work he did with Tom. Congratulations!
Ingrid has left us for a position at the Heinrich-Heine-Univerisät Düsseldorf. Congratulations and good luck!
Amy was inducted into the American Academy of Arts and Sciences.
Amy received the Ivano Bertini Award at the Ninth International Copper Meeting. Congratulations!
Grace received the Rappaport Award for Research Excellence. Congratulations!
Rahul Purohit has joined the group as a postdoctoral researcher. Rahul received his PhD in chemistry for work done in the lab of Dr. William Montfort at the University of Arizona.
Megen's paper on the structure of methanol dehydrogenase is published in Biochemistry. Read the article.
Sarah successfully defended her PhD thesis. Congratulations!
Soo Ro has joined the group as a graduate student. Soo obtained her undergraduate degree in integrative biology from the University of California, Berkeley.
Megen's paper on EPR studies of pMMO metal centers is published in JACS. Read the article.
Megen has left us to become an Assistant Professor at Appalachian State University.. Congratulations and good luck!
Sarah's paper on the effects of zinc on pMMO is published in the Journal of Biological Chemistry. Read the article.
Amy received the Royal Society of Chemistry Joseph Chatt Award.
Amy was elected to the American Academy of Arts and Sciences.
Aaron's article on the diversity of metal-transporting ATPases is published in the Journal of Biological Inorganic Chemistry. Read the article.
Tom's article on conservation of the B subunit in particulate methane/ammonia monooxygenases is published in Proteins: Structure, Function, and Bioinformatics. Read the article.
Eliza's article on a nickel- and iron-transporting P1B-type ATPase is published in Metallomics. Read the article.
Eliza has left us to take up a postdoctoral research position at Argonne National Laboratory. Good luck!
Laura Dassama joined the group as a postdoctoral fellow. Laura comes from the joint lab of Profs. Carsten Krebs and J. Martin Bollinger Jr. at Penn. State.
Laura and Amie's article on class 1c ribonucleotide reductases is published in Biochemistry. Read the article.
Amie has left us to become an Assistant Professor at Penn State. Congratulations and good luck!
Tom's article on a nitrite reductase involved in nitrifier denitrification is published in the Journal of Biological Chemistry. Read the article.
Tom successfully defended his PhD thesis. Congratulations!
Eliza successfully defended her PhD thesis. Congratulations!
Amy was invested as the Weinberg Family Distinguished Professor of Life Sciences.
Amy's News and Views article on soluble methane monooxygenase is published in Nature Chemical Biology. Read the article.
Grace's paper on detection of new methanobactins in genomes is published in BMC Biology. Read the article.
Tom Lawton was elected Chair of the 2015 Bioinorganic Chemistry Graduate Research Seminar.
Rosenzweig lab alums Raquel Lieberman (Georgia Tech), Matt Sazinsky (Pomona College), and Liliya Yatsunyk (Swarthmore College) were all promoted to Associate Professor with tenure. Congratulations!