Selected Publications from the Carthew Lab

2011                                                                                                                      

Biological robustness and the role of microRNAs: a network perspective.

Pelaez, N., and R.W. Carthew 

Curr. Topics Dev. Biol. in press (2011)

 

Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing.

Harris, D.A., Kim, K., Nakahara, K., Vazquez-Doorman, C. and R.W. Carthew

J. Cell Biol. 194, 77-87 (2011)

 

Cadherin-dependent cell morphology in an epithelium: constructing a quantitative dynamical model.

Gemp, I., Carthew, R.W. and S. Hilgenfeldt 

PLOS Comp. Biol. 7, e1002115 (2011)

 

2010                                                                                                                    

Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila.

Marques, J.T., Kim, K., Wu, P-H., Alleyne, T., Jafari, N. and R.W. Carthew

Nature Struct. Mol. Biol. 17, 24-30 (2010)

 

Evolutionary flux of canonical microRNAs and mirtrons in Drosophila.

Lu, J., Shen, Y., Carthew, R.W., Wang, S.M. and C.I. Wu

Nature Genetics 42, 9–10 (2010)

 

2009                                                                                                                      


The endo-siRNA pathway is required for robust development of the Drosophila embryo.

Lucchetta, E.M., Carthew, R.W. and R.F. Ismagilov


PLOS One 4, e7576 (2009)

 

A microRNA imparts robustness against environmental fluctuation during development.

Li, X., Cassidy, J., Reinke, C.A., Fischboeck, S. and R.W. Carthew


Cell 137, 273-282 (2009)

 

Silencing by small RNAs is linked to endosomal trafficking.


Lee, Y.S., Pressman, S., Andress, A.P., Kim, K.,, White, J.L., Cassidy, J.J., Li, X., Lubell, K., Lim, D.H., Cho, I.S., Nakahara, K., Preall, J.B., Bellare, P., Sontheimer, E.J. and R.W. Carthew 


Nature Cell Biol. 11, 1150-1156 (2009)

 

Origins and mechanisms of miRNAs and siRNAs.

Carthew, R.W. and E.J. Sontheimer

Cell 136, 642-655 (2009)


 

2008                                                                                                                       


Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye.

Zheng, L and R.W. Carthew


Mech. Dev. 125, 18-29 (2008)


 

BMP signaling goes post-transcriptional in a microRNA-sort of way. 

Reinke, C.A. and R.W. Carthew 


Dev. Cell 15, 174-175 (2008)


 

The birth and death of microRNA genes in Drosophila.

Lu, J., Shen, Y., Wu, Q., Kumar, S., He, B., Carthew, R.W., Wang, S. and C.I. Wu 


Nature Genetics 40, 351-355 (2008)


 

Adaptive evolution of newly-emerged microRNA genes in Drosophila.

Lu, J., Fu, Y., Kumar, S., Shen, Y., Zeng, K., Carthew, R.W. and C.I. Wu


Mol. Biol. Evol. 25, 929-938 (2008)


 

Functional analysis of Dicer-2 missense mutations in the siRNA pathway of Drosophila.

Lim, D-W., Kim, J., Kim, S., Carthew, R.W. and Y.S. Lee 


Biochim. Biophys. Res. Comm. 37, 525-530 (2008)


 

Physical modeling of cell geometric order in an epithelial tissue.


Hilgenfeldt, S., Erisken, S. and R.W. Carthew


Proc. Nat. Acad. Sci. USA 105, 907-911 (2008)


 

Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye.


Hayashi, T., Xu, C. and R.W. Carthew


Development 135, 2787-2796 (2008)


 

2007                                                                                                                       


Post transcriptional gene silencing.


Pressman, S., Bei, Y and R.W. Carthew


Cell 130, 570 (2007)


 

A call to arms: co-evolution of animal viruses and host innate immune responses.

Marques J.T. and R.W. Carthew


Trends Genetics 23, 359-364 (2007)


 

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes.

Kim K., Lee, Y.S. and R.W. Carthew


RNA 13, 22-29 (2007)

 

Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina.

Käfer, J., Hayashi, T., Marée, A.F.M., Carthew, R.W. and F. Graner

Proc. Nat. Acad. Sci. USA 104, 18549-18554 (2007)

 

Pattern formation in the Drosophila eye.

Carthew R.W.

Curr. Opin. Genet. Dev. 17, 309-313 (2007)


 

Small RNA-mediated epigenetic modifications.

Bei, Y., Pressman, S. and R.W. Carthew

Cell 130, 665 (2007)

 

2006                                                                                                                       

RNA interference directs innate immunity against viruses in adult Drosophila.

Wang X-H., Aliyari R., Li W-X., Li H-W., Kim K., Carthew R.W., Atkinson P. and X-W. Ding

Science 312, 452-454 (2006)


 

The RNAi Pathway Initiated by Dicer-2 in Drosophila.

Kim K., Lee Y.S., Harris D., Nakahara K. and R.W. Carthew

Cold Spring Harbor Symp. Quant. Biol. 71, 39-44 (2006)


 

Gene regulation by microRNAs.

Carthew R.W.

Curr. Opin. Genet. Dev. 16, 203-208 (2006)


 

A new RNA dimension to genome control.


Carthew R.W. 

Science 313, 305-306 (2006)

 

Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo.


Bayraktar J, Zygmunt D. and R.W. Carthew 

J Cell Sci. 119, 711-721 (2006)




2005                                                                                                                       


Functional roles of endogenous miRNAs and siRNAs.

Sontheimer E.J. and R.W. Carthew

Cell 122, 9-12 (2005)


 

Targets of microRNA regulation in the Drosophila oocyte proteome.


Nakahara K., Kim K., Sciulli C., Dowd S.R., Minden J.S. and R.W. Carthew


Proc. Nat. Acad. Sci. USA 102, 12023-12028 (2005)


 

A miRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye.


Li X. and R.W. Carthew


Cell 123, 1267-1277 (2005)


 

Stem cell division is regulated by the microRNA pathway.

Hatfield S.D., Shcherbata H.R., Fischer K.A., Nakahara K., Carthew R.W. and H. Ruohola-Baker.


Nature 435, 974-978 (2005)


 

Adhesion proteins and control of cell shape.


Carthew R.W.


Curr. Opin. Genet. Dev. 15, 358-363 (2005)



 

2004                                                                                                                       

Argonaute Journeys into the Heart of RISC.


Sontheimer E.J. and R.W. Carthew


Science 305, 1409-1410 (2004)


 

A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila.


Pham J.W., Pellino J.L., Lee Y.S., Carthew R.W. and E.J. Sontheimer 


Cell 117, 83-94 (2004)


 

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.


Lee Y.S., Nakahara K., Pham J.W., Kim K., He Z., Sontheimer E.J. and R.W. Carthew 


Cell 117, 69-81 (2004)


 

Surface mechanics mediate pattern formation in the developing retina.

Hayashi T. and R.W. Carthew


Nature 431, 647-652 (2004)


 

Genome wide survey of protein kinases required for cell cycle progression.


Bettencourt-Dias M., Giet R., Sinka R., Mazumdar A., Lock W.G., Balloux F., Zafiropoulos P.J., Yamaguchi S., Winter S., Carthew R.W., Cooper M., Jones D., Frenz L. and D.M. Glover


Nature 432, 980-987 (2004)

 

2003                                                                                                                       

Chibby, a nuclear ß-catenin-associated antagonist of the Wnt/Wingless pathway.


Takemaru K-I., Yamaguchi S., Lee Y.S., Zhang Y., Carthew R.W. and R.T. Moon


Nature 422, 905-909 (2003)



 

Making a better RNAi vector for Drosophila: Use of Intron Spacers.

Lee Y.S. and R.W. Carthew


Methods 30, 322-329 (2003)


 

2002                                                                                                                       

Phyllopod acts as an adaptor protein to link the Sina ubiquitin ligase to the substrate protein Tramtrack.


Li S., Xu C. and R.W. Carthew


Mol. Cell. Biol. 22, 6854-6865 (2002)

 

RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E.


Kennerdell J.R., Yamaguchi S. and R.W. Carthew


Genes Dev. 16, 1884-1889 (2002)


 

2000                                                                                                                       

Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye.


Xu C., Kauffmann R.C., Zhang J., Kladny S. and R.W. Carthew


Cell 103, 87-97 (2000)

 

Heritable gene silencing in Drosophila using double-stranded RNA.


Kennerdell J.R. and R.W. Carthew


Nature Biotechnology 18, 896-898 (2000)


 

1999                                                                                                                       


Ebi regulates epidermal growth factor receptor signaling pathways in Drosophila.


Dong X., Tsuda L., Zavitz K.H., Lin M., Li S., Carthew R.W. and S.L. Zipursky


Genes Dev. 13, 954-965 (1999)



 

1998                                                                                                                       

Interactions between Wingless and DFz2 during Drosophila wing development.


Zhang J. and R.W. Carthew


Development 125, 3075-3085 (1998)



Proteasomal regulation of nuclear receptor corepressor-mediated repression.


Zhang J., Guenther M.G., Carthew R.W. and M.A. Lazar


Genes Dev. 12, 1775-1780 (1998)


 

Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled2 act in the Wingless pathway.

Kennerdell, J.R. and R.W. Carthew


Cell 95, 1017-1026 (1998)

 

1997                                                                                                                       


Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack.


Li S., Li Y., Carthew R.W. and Z.-C. Lai


Cell 90, 469-478 (1997)

 

1996                                                                                                                       

Ras1 signaling and transcriptional competence in the R7 cell of Drosophila.


Kauffmann R.C., Li S., Gallagher P.A., Zhang J. and R.W. Carthew


Genes Dev. 10, 2167-2178 (1996)


 

1995                                                                                                                       


Frizzled regulates mirror-symmetric pattern formation in the Drosophila eye.

Zheng L., Zhang J. and R.W. Carthew


Development 121, 3045-3055 (1995)

 

Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.


Kauffmann R.C., Qian, Y., Vogt, A., Sebti, S.M., Hamilton, A.D. and R.W. Carthew


Proc. Nat. Acad. Sci. USA 92, 10919-10923 (1995)



1994                                                                                                                       

Identification of genes that interact with the sina gene in Drosophila eye development.


Carthew, R.W., Neufeld, T. and G.M. Rubin

Proc. Nat. Acad. Sci. USA 91, 11689-11693 (1994)