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A
drug which attenuates the effects of an agonist. Antagonism
can be competitive and reversible (i.e. it binds reversibly
to a region of the receptor in common with the agonist.)
or competitve and irreversible (i.e.antagonist binds covalently
to the agonist binding site, and no amount of agonist
can overcome the inhibition). Other types of antagonism
are non-competitive antagonism where the antagonist binds
to an allosteric site on the receptor or an associated
ion channel. |
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