Genes / Proteins | Definitions | Models | Developmental Models | General Concepts | Contribute/Corrections | Links | Protocols | Home         Achaete a proneural gene Apterous a LIM-homeodomain protein Araucan a member of the iroquois complex (Iro-C) Armadillo . Blistered Drosophila serum response factor (D-SRF) Casein Kinase 1 a kinase Caupolican a member of the iroquois complex (Iro-C) CBP a transcriptional co-activator Costal-2 kinesin like protein involved in hedgehog signaling and acts by anchoring Cubitus interruptus in the cytoplasm Cubitus interruptus Zinc finger transcription factor that mediates Hedgehog signaling Cul1 functions as a scaffold protein within the SCF complex which functions as ubiquitin E3 ligase Cut transcription factor - homeodomain - cut domain - mediates choice between chordotonal sense organ and external sensory organ fate - also involved in wing and follicle cell morphogenesis Decapentaplegic ligand with tgf-beta homology involved early to establishes embryonic dorsal/ventral and later patterns appendages Delta transmembrane - EGF family - Notch ligand - important in establishing neural cell fates Dishevelled . Dispatched patched family protein regulating Hedgehog release EGFR transmembrane receptor- tk - EGF-R homology - during oogenesis helps set up egg polarity, determines the identity of cells in the ectoderm; during larval stages participates in the development of the eye and wing. Engrailed transcription factor - homeodomain - engrailed class - segment polarity gene - involved in compartment identity and boundary formation Extramacrochaetae a helix-loop-helix protein lacking a basic motif shown to be involved in the control of cell proliferation in the wing Fused serine/threonine kinase - segment polarity gene - cytoplasmic component of Hedgehog signaling pathway Gli proteins mamalian homologues of Ci GSK3 serine/threonine kinase - cytoplasmic component of Hedgehog and Wingless signaling pathway Hedgehog a segment polarity intercellular signaling protein Knot required for the formation of the hypopharyngeal lobe, the proper development of the larval head skeleton, and suppresses vein formation between veins 3 and 4 Mirror a member of the iroquois complex (Iro-C) Mothers against Dpp novel protein - downstream of DPP - Smad family members convey TGF¨ signals from their receptors to the nucleus nejire (see CBP) Nedd8 ubiquitin-like small protein modifier Notch . Openbrain . Optomotor-blind . Patched transmembrane - segment polarity gene - receptor for Hedgehog PKA . PKAc . PKAr . Rhomboid serine protease - transmembrane protein involved with Epidermal growth factor receptor signaling - required for the production or processing of Spitz, the Egfr ligand Roc1 a Ring finger protein in SCF complex Scalloped . Scute a proneural gene Serrate . Serum response factor AKA: blistered Sex-lethal . Shavenbaby . Skp1 an adaptor protein that links Cullins with the F-box protein Smoothened . Sonic Hedgehog mammalian Hedgehog homologue Spitz . Supernumerary limbs F-box protein involved in Ci degradation Suppressor of fused novel PEST domain containing protein involved in Hedgehog signaling Vein a secreted neuregulin-like molecule that activates EGFR signaling and is a candidate moledule for establishing the notum Vestigial a wing specific gene Wingless .          Genes / Proteins  |  Definitions  |  Models  |  Developmental Models  |  General Concepts  |  Contribute/Corrections  |  Links  |  Protocols  |  Home Website created and maintained by: Mark Lefers and the Holmgren Lab last updated: June 11, 2004