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- EMS alkylates guanine at the O6 position, forming O6-ethylguanine
(Et-G), which base pairs with thymine
- Two rounds of DNA replication change a Et-G—C base pair to a
A—T pair
- Cells also have repair enzymes that can remove the thyl group from
Et-G
- EMS mutagenesis can also lead to deletions
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