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- Related to the Hh pathway
- Disruption in pathway leads to several dieseses:
- Basal cell carcinoma (BCC): over-expression of Gli1
- Holoproensephaly (sp?): 1/250 pregnancie
- Shh is essential for:
- inducing the formation of ventral cell types in the vertebrate
neural tube (Briscoe,
1999)
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