Armadillo

Armadillo

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{Models}

{Summary}

Function/Pathway

arm is a downstream effector of wingless signal transduction and is also a component of Cadherin-based adhesion complexes (Orsulic, 1996)

Genetic interactions

DE-Cadherin
- Armadillo is titrated out of its signaling pool when DE-Cadherin is overexpressed, and in the embryonic epidermis, this leads to a phenocopy of a wingless mutation (Sanson, 1996).
  - Overexpressed Cadherin blocks the response to Wingless in a cell-autonomous manner
- clones of cells expressing DE-Cadherin, which blocks wg signaling, located in naked regions make ectopic denticles. Clones within the denticle belts have no effect (Sanson, 1999)
Ectopic expression of Wg, Dsh, or a dominant-active form of Arm (Arm^S10) in a fu¹ mutant driven in the wing pouch by 71B-GAL4 results in a decrease in Col expression (Fig 5) (Glise, 2002)

Physical interactions

{Physical interactions}

Transcriptional Regulation

{Regulation}

Structure

{Structure}

Location (protein and transcript)

{Location}

Protein Modifications and Regulation

{Modifications}

Related to

{Related to}

Mutations

{Mutations}

Overexpression / Ectopic expression

Ectopic expression of Wg, Dsh, or a dominant-active form of Arm (Arm^S10) in a fu¹ mutant driven in the wing pouch by 71B-GAL4 results in a decrease in Col expression (Fig 5) (Glise, 2002)

Reagents

{Reagents}