CBP

CREB-binding protein

Add Correction Suggestion

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{Summary}

Function/Pathway

Originally identified as a coactivator for CREB, enhances transcription mediated by many other transcription factors
Functions as a coactivator of Ci; is needed for ptc expression (Akimaru, 1997) and 4bslacZ (my data)

Genetic interactions

dCBP is probably required for Ci activation and not Ci repression because CBP mutant clones don’t lead to Hh expression like Ci mutant clones do. (Ci-rep represses Hh expression) (Akimaru, 1997)
Ci requires CREB-binding protein to activate wg expression in the embryo ( Chen, 2000)

Physical interactions

Transcriptional Regulation

{Regulation}

Structure

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Location (protein and transcript)

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Protein Modifications and Regulation

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Related to

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Mutations

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Overexpression / Ectopic expression

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Reagents

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