{Models}
| Symbol: Symbol: Dpp {Links}
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Flybase ID: {Flybase_ID} |
| Synonyms: {Name}
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{GadFly} |
| Function: {Short_Function} |
{LocusLink} |
| Keywords: {Keywords} |
{Interactive_Fly} |
- A secreted TGF-b family member
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- The amount of Dpp protein secreted from the AP border dictates the
position at which vein 2 forms (Sturtevant,
1997)
- Can exert a long-range organizing influence on surrounding wing tissue,
specifying anterior or posterior patterning depending on the compartmental
provenance, and hence the state of en activity, of the responding cells
(Burke,
1999)
- During the 3rd larval instar Dpp activates genes: omb and sal, at
distinct threshold levels to create nested domains of transcription
factor expression across the wing
- Hh signaling
- Expression is lost in ci clones missing the transactivation domain
(Hepker,
1999)
- In smo clones (no Hh signaling) dpp-lacZ, Ptc and anterior En
expression is inhibited, suggesting that they are direct targets
for regulation by Hh signaling (Strigini,
1997)
- in Pka-C1 mutants in the anterior compartment Col, Ptc, and En are
up regulated but only at some distance away from the DV boundary (Figs.
3A-3C) (Glise, 2002)
- did not observe any modulation of dpp-lacZ staining along
the DV axis, possible do to perdurance
of B-galactosidase (Glise, 2002)
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- Dpp-lacZ is expressed in a stripe several cells anterior to the lineage
boundary, and did not define or overlap into the posterior lineage compartment
(Blair,
1992)
- Mutant clones lacking both en and invected ectopically express dpp-lacZ
and ptc in the posterior compartment where dpp activity ordinarily is
repressed (Sanicola,
1995)
- A minimal dpp disc enhancer was able to respond to the full length
and repressor forms of Ci and that their activities can br replaced
by a single synthetic Gli-binding site (Muller,
2000)
- Expression in all imaginal discs is dependent on a 30kb 3’cis
regulatory region, the disc region
- En fxns as a transcriptional repressor in this region
- dpp heldout (dppho) is a 358 bp wing- and haltere-specific element
within the disc region
- expression is spatially determined by dTCF, GLI/Ci, the Vestigial/Scalloped
selector system, and temporally controlled by dpp autoregulation (Hepker,
1999)
- contain GLI/Ci consensus binding sites, which are required (Hepker,
1999)
- dpp transcription is regulated by a combination of Ci[act] and Ci[rep]
activities (Methot,
1999)
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- The carboxy-terminal 100 amino acids have 25-40% homology to human
and porcine TGFbeta, Inhibin A and Inhibin B. The homologous region
is preceded by three arginine dimers that each function as proleolytic
cleavage sites.
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- secreted
- dpp expression is not up regulated in the central row of cells corresponding
to the prospective wing margin (Fig 1N). This region of refractory to
Hh signaling exists along the entire DV boundary. See (Glise, 2002)
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