Dispatched

Dispatched

Add Correction Suggestion

{Models}

{Summary}

Function/Pathway

Disp is required only in P cells for effective Hh signaling to A cells. In the absence of Disp, Hh is retained in P cells, and its access to A cells is severely limited. In contrast, Hh-Nu is unaffected by the absence of Disp, indicating that the cholesterol anchor is responsible for the retention of Hh in disp mutant cells. Our results indicate that Hh-Np is indeed a tethered protein but that its retention is overcome by the activity of the dedicated SSD (sterol-sensing domain) protein, Disp. (Burke, 1999)
Only needed in Hh producing cells (Burke, 1999)
(Burke, 1999) suggest that Disp acts in some way to displace Hh-Np from the lipid rafts to which it is targeted by its cholesterol moiety.

Genetic interactions

{Genetic interations}

Physical interactions

{Physical interactions}

Transcriptional Regulation

{Regulation}

Structure

{Structure}

Location (protein and transcript)

{Location}

Protein Modifications and Regulation

{Modifications}

Related to

Share structural homology with Ptc in the form of a sterol-sensing domain
- Possession of an SSD suggests a role in vesicle trafficking, or like its C. elegans counterpart CHE14 (Michaux, 2000), Disp might plays a role in apico–basal sorting of Hh.

Mutations

In the absence of Disp, cholesterol-modified but not cholesterol-free Hh is retained in P cells, indicating that Disp fxns to release cholesterol-anchored Hh (Burke, 1999)

Overexpression / Ectopic expression

{Overexpression}

Reagents

{Reagents}