Notch

Notch

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{Summary}

Function/Pathway

During second larval instar, N and Wg define the DV boundary, which will eventually give rise to a specialised vein structure: the wing margin

Genetic interactions

In col¹ mutants, N is downregulated in the L3m provein domain (data not shown) (Crozatier, 2002) .

Physical interactions

{Physical interactions}

Transcriptional Regulation

{Regulation}

Structure

{Structure}

Location (protein and transcript)

Levels of N protein are high in intervein regions and low in presumptive vein territories in late third instar (De Celis et al., 1997).

Protein Modifications and Regulation

{Modifications}

Related to

{Related to}

Mutations

When N^ts2 larvae are shifted to nonpermissive temperature at the beginning of L3 Col and Ptc expression is not repressed in cells corresponding to the prospective wing margin (Figs 6A & 6B), and surviving adults exhbit notches at the distal tip of the wings (Fig 6J), reminiscent of the most sensitive phenotype observed in the wings of adult flies heterzygous for N^55e11, a null allele of N (Fig 6I) (Glise, 2002)

Overexpression / Ectopic expression

Ectopically expressed N^intra (a dominat active form) produces a cell-autonomous down-regulation of both Col and Ptc (Fig 6C and 6D). By contrast, expression of En was not affected by Nintra expression in either the posterior compartment or the anterior compartment in response to Hh (Fig. 6E), consistent with the fact that en is normally activated in the prospective wing margin (Glise, 2002)

Reagents

{Reagents}