Openbrain

Openbrain

Add Correction Suggestion

{Models}

Symbol: Opb encodes Rab23 vertebrate gene {Links}	Flybase ID: {Flybase_ID}
Synonyms: {Name}	{GadFly}
Function: {Short_Function}	{LocusLink}
Keywords: {Keywords}	{Interactive_Fly}

{Summary}

Function/Pathway

Rab proteins in general are master regulators of vesicle trafficking. Acting as scaffolds they coordinate the budding of vesicles form one cellular compartment, their transport, and their docking and fusion with the target compartments

Genetic interactions

Physical interactions

{Physical interactions}

Transcriptional Regulation

{Regulation}

Structure

{Structure}

Location (protein and transcript)

mRNA expression pattern was similar to Gli3 (Eggenschwiler 2001), another negative regulator of the Shh signalling pathway.

Protein Modifications and Regulation

{Modifications}

Related to

{Related to}

Mutations

Mutations have defects that are characteristic of overactive Shh signalling – for example, suppression of dorsal and overproduction of ventral neuronal precursors.
Shh/opb double mutants look like opb single mutant (Eggenschwiler 2001)
Homozygous mutants die during the second half of gestation, with an open neural tube in the head and spinal cord, abnormal somites, polydactyly, and poorly developed eyes (Eggenschwiler 2001) — These phenotypes resemble those produced by partial loss of function of Ptc

Overexpression / Ectopic expression

{Overexpression}

Reagents

{Reagents}