PKAr

PKAr

Add Correction Suggestion

{Models}

{Summary}

Function/Pathway

{Function/Pathway}

Genetic interactions

{Genetic interations}

Physical interactions

Binding of 4 cAMP molecules in domains A and B is required to dissociate the PKAc from PKAr

Transcriptional Regulation

{Regulation}

Structure

Two regulatory subunits type I monomers dimerize in reverse orientation and are covalently linked by disulfide bonds between the pairs of cysteine residues in the dimerization domains to give PKAr
The dimerization domain also contains residues that are essential for PKAr type I binding to dual specificity A-kinase anchoring proteins

Location (protein and transcript)

{Location}

Protein Modifications and Regulation

{Modifications}

Related to

{Related to}

Mutations

PKAr*, defective in binding cAMP, is shown to activate Hh target genes solely through its ability to bind and inhibit endogenous PKAc (Kiger, 2001)
However PKI(1-31), a small fragment of the rabbit skeletal muscle PKAc-inhibitor protein, is unable to have an effect despite its ability to inhibit endogenous PKAc (Kiger, 2001)

Overexpression / Ectopic expression

{Overexpression}

Reagents

{Reagents}