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Recent Publications

Membrane, Lipid and Transfection Studies

Tarahovsky YS, Rakhmanova VA, Epand RM, MacDonald RC.
High temperature stabilization of DNA in complexes with cationic lipids.
Biophysical J. 2002 Jan;82(1):264-273

Huang SL, Hamilton AJ, Pozharski E, Nagaraj A, Klegerman ME, McPherson DD, MacDonald RC.
Physical correlates of the ultrasonic reflectivity of lipid dispersions suitable as diagnostic contrast agents.
Ultrasound Med Biol. 2002 Mar;28(3):339-348.

Huang SL, Hamilton AJ, Nagaraj A, Tiukinhoy SD, Klegerman ME, McPherson DD, Macdonald RC.
Improving ultrasound reflectivity and stability of echogenic liposomal dispersions for use as targeted ultrasound contrast agents.
J Pharm Sci. 2001 Dec;90(12):1917-26.

Rosenzweig HS, Rakhmanova VA, MacDonald RC.
Diquaternary ammonium compounds as transfection agents.
Bioconjug Chem. 2001 Mar-Apr;12(2):258-63.

Garcia RA, Pantazatos SP, Pantazatos DP, MacDonald RC.
Cholesterol stabilizes hemifused phospholipid bilayer vesicles.
Biochim Biophys Acta. 2001 Apr 2;1511(2):264-70.

Pozharski EV, McWilliams L, MacDonald RC.
Relationship between turbidity of lipid vesicle suspensions and particle size.
Anal Biochem. 2001 Apr 1;291(1):158-62. No abstract available.

Tiukinhoy SD, Mahowald ME, Shively VP, Nagaraj A, Kane BJ, Klegerman ME,
MacDonald RC, McPherson DD, Matsumura JS.
Development of echogenic, plasmid-incorporated, tissue-targeted cationic liposomes that can
be used for directed gene delivery.
Invest Radiol. 2000 Dec;35(12):732-8.

Tarahovsky YS, Arsenault AL, MacDonald RC, McIntosh TJ, Epand RM.
Electrostatic control of phospholipid polymorphism.
Biophys J. 2000 Dec;79(6):3193-200.

Rosenzweig HS, Rakhmanova VA, McIntosh TJ, MacDonald RC.
O-Alkyl dioleoylphosphatidylcholinium compounds: the effect of varying alkyl chain length on
their physical properties and in vitro DNA transfection activity.
Bioconjug Chem. 2000 May-Jun;11(3):306-13.

Kennedy MT, Pozharski EV, Rakhmanova VA, MacDonald RC.
Factors governing the assembly of cationic phospholipid-DNA complexes.
Biophys J. 2000 Mar;78(3):1620-33.

MacDonald RC, Ashley GW, Shida MM, Rakhmanova VA, Tarahovsky YS, Pantazatos DP, Kennedy MT, Pozharski EV, Baker KA, Jones RD, Rosenzweig HS, Choi KL, Qiu R, McIntosh TJ.
Physical and biological properties of cationic triesters of phosphatidylcholine
Biophys J. 1999 Nov;77(5):2612-29.

MacDonald RC, Rakhmanova VA, Choi KL, Rosenzweig HS, Lahiri MK.
O-ethylphosphatidylcholine: A metabolizable cationic phospholipid which is a serum-compatible
DNA transfection agent.
J Pharm Sci. 1999 Sep;88(9):896-904.

Matsumura JS, Kim R, Shively VP, MacDonald RC, Pearce WH.
Characterization of vascular gene transfer using a novel cationic lipid.
J Surg Res. 1999 Aug;85(2):339-45.

Pantazatos DP, MacDonald RC.
Directly observed membrane fusion between oppositely charged phospholipid bilayers.
J Membr Biol. 1999 Jul 1;170(1):27-38.

Rakhmanova VA, MacDonald RC.
A microplate fluorimetric assay for transfection of the beta-galactosidase reporter gene.
Anal Biochem. 1998 Mar 15;257(2):234-7.

Spectrin Characterization Studies

MacDonald RI, Pozharski EV.
Free energies of urea and of thermal unfolding show that two tandem repeats of spectrin are thermodynamically more stable than a single repeat.
Biochemistry. 2001 Apr 3;40(13):3974-84.

Grum VL, Li D, MacDonald RI, Mondragon A.
Structures of two repeats of spectrin suggest models of flexibility.
Cell. 1999 Aug 20;98(4):523-35.

Pantazatos DP, MacDonald RI.
Site-directed mutagenesis of either the highly conserved Trp-22 or the moderately conserved Trp-95 to a large, hydrophobic residue reduces the thermodynamic stability of a spectrin repeating unit.
J Biol Chem. 1997 Aug 22;272(34):21052-9.

MacDonald RI, Musacchio A, Holmgren RA, Saraste M.
Invariant tryptophan at a shielded site promotes folding of the conformational unit of spectrin.
Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1299-303.

MacDonald RI.
Temperature and ionic effects on the interaction of erythroid spectrin with phosphatidylserine membranes.
Biochemistry. 1993 Jul 13;32(27):6957-64.