LAMB LABORATORY



HOME



RESEARCH



PUBLICATIONS



LAB MEMBERS



NEWCOMER'S CHECKLIST



FINDING US



LINKS



JOIN THE LAMB LAB

 

PUBLICATIONS



Publications (click here to connect to access PubMed)

1975-1979 1980-19891990-19992000-2004200520062007200820092010201120122013 2014201520162017

1975-1979 -back to top

(click on no. to access publication in PubMed)

1. Lamb, R.A. (1975). The phosphorylation of Sendai virus proteins by a virus particle-associated protein kinase. J. Gen. Virol. 26, 249-263.

2. Lamb, R.A., B.W.J. Mahy and P.W. Choppin. (1976). The synthesis of Sendai virus polypeptides in infected cells. Virology 69, 116-131.

3. Inglis, S.C., A.R. Carroll, R.A. Lamb and B.W.J. Mahy. (1976). Polypeptides specified by the influenza virus genome. I. Evidence for eight distinct gene products specified by fowl plague virus. Virology 74, 489-503.

4. Lamb, R.A. and P.W. Choppin. (1976). Synthesis of influenza virus proteins in infected cells: Translation of viral polypeptides, including three P polypeptides, from RNA produced by primary transcription. Virology 74, 504-519.

5. Peluso, R.W., R.A. Lamb and P.W. Choppin. (1977). Polypeptide synthesis in simian virus 5-infected cells. J. Virol. 23, 177-187.

6. Lamb, R.A. and P.W. Choppin. (1977). The synthesis of Sendai virus polypeptides in infected cells. II. Intracellular distribution of polypeptides. Virology 81, 371-381.

7. Lamb, R.A. and P.W. Choppin. (1977). The synthesis of Sendai virus polypeptides in infected cells. III. Phosphorylation of polypeptides. Virology 81, 382-397.

8. Lamb, R.A. and P.W. Choppin. (1977). Synthesis of influenza virus polypeptides in cells resistant to alpha-Amanitin: Evidence for the involvement of cellular RNA polymerase II in virus replication. J. Virol. 23, 816-819.

9. Lamb, R.A. and P.W. Choppin. (1978). Determination by peptide mapping of the unique polypeptides in Sendai virions and infected cells. Virology 84, 469-478.

10. Lamb, R.A., P.R. Etkind and P.W. Choppin. (1978). Evidence for a ninth influenza viral polypeptide. Virology 91, 60-78.

11. Peluso, R.W., R.A. Lamb and P.W. Choppin. (1979). Infection with paramyxoviruses stimulates synthesis of cellular polypeptides which are also stimulated in cells transformed by Rous sarcoma virus or deprived of glucose. Proc. Natl. Acad. Sci. USA 75, 6120-6124.

12. Hall, W.W., R.A. Lamb and P.W. Choppin. (1979). Measles and subacute sclerosing panencephalitis virus proteins: Lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proc. Natl. Acad. Sci. USA 76, 2047-2051.

13. Lamb, R.A. and P.W. Choppin. (1979). Segment 8 of the influenza virus genome is unique in coding for two polypeptides. Proc. Natl. Acad. Sci. USA 76, 4908-4912.

1980-1989 -back to top

14. Etkind, P.R., R.K. Cross, R.A. Lamb, D.C. Merz and P.W. Choppin. (1980). In vitro synthesis of structural and nonstructural proteins of Sendai and SV5 viruses. Virology 100, 22-33.

15. Hall, W.W., R.A. Lamb and P.W. Choppin. (1980). The polypeptides of canine distemper virus: Synthesis in infected cells and relatedness to the polypeptides of other morbilliviruses. Virology 100, 433-449.

16. Lamb, R.A. and P.W. Choppin. (1980). A ninth unique influenza virus-coded polypeptide. Trans. R. Soc. Lond. B. 288, 327-333.

17. Lamb, R.A., P.W. Choppin, R.M. Chanock and C.-J. Lai. (1980). Mapping of the two overlapping genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus genome. Proc. Natl. Acad. Sci. USA 77, 1857-1861.

18. Lai, C.-J., L.J. Markoff, M.M. Sveda, R.A. Lamb, R. Dhar and R.M. Chanock. (1980). Genetic variation of influenza A viruses as studied by recombinant DNA techniques. Annals N.Y. Acad. Sci. 354, 162-171.

19. Lamb, R.A. and C.-J. Lai. (1980). Sequence of interrupted and uninterrupted mRNAs and cloned DNA coding for the two overlapping nonstructural proteins of influenza virus. Cell 21, 475-485.

20. Briedis, D.J., R.A. Lamb and P.W. Choppin. (1981). Influenza B virus RNA segment 8 codes for two nonstructural proteins. Virology 112, 417-425.

21. Lamb, R.A. and C.-J. Lai. (1981). Conservation of the influenza virus membrane protein (M1) amino acid sequence and an open reading frame of RNA segment 7 encoding a second protein (M2) in H1N1 and H3N2 strains. Virology 112, 746-751.

22. Lamb, R.A. and P.W. Choppin. (1981). Identification of a second protein (M2) encoded by RNA segment 7 of influenza virus. Virology 112, 729-737.

23. Lamb, R.A., C.-J. Lai and P.W. Choppin. (1981). Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: Colinear and interrupted mRNAs code for overlapping proteins. Proc. Natl. Acad. Sci. USA 78, 4170-4174.

24. Briedis, D.J. and R.A. -Lamb. (1982). Influenza B virus genome: Sequences and structural organization of RNA segment 8 and the mRNAs coding for the NS1 and NS2 proteins. J. Virol. 42, 186-193.

25. Briedis, D.J., R.A. Lamb and P.W. Choppin. (1982). Sequence of RNA segment 7 of the influenza B virus genome: Partial amino acid homology between the membrane proteins (M1) of influenza A and B viruses and conservation of a second open reading frame. Virology 116, 581-588.

26. Shaw, M.W., R.A. Lamb, B.W. Erickson, D.J. Briedis and P.W. Choppin. (1982). Complete nucleotide sequence of the neuraminidase gene of influenza B virus. Proc. Natl. Acad. Sci. USA 79, 6817-6821.

27. Lamb, R.A. and C.-J. Lai. (1982). Spliced and unspliced messenger RNAs synthesized from cloned influenza virus M DNA in an SV40 vector: Expression of the influenza virus membrane protein (M1). Virology 123, 237-256.

28. Strickland, S. and R.A. Lamb. (1983). Infection of mouse teratocarcinoma stem cells with influenza virus: Normal expression of proteins derived from spliced messenger RNAs. Devel. Biol. 97, 506-509.

29. Lamb, R.A. and P.W. Choppin. (1983). The gene structure and replication of influenza virus. Annu. Rev. Biochem. 52, 467-506.

30. Shaw, M.W., P.W. Choppin and R.A. Lamb. (1983). A previously unrecognized influenza B virus glycoprotein from a bicistronic mRNA that also encodes the viral neuraminidase. Proc. Natl. Acad. Sci. USA 80, 4879-4883.

31. Lamb, R.A. and C.-J. Lai. (1984). Expression of unspliced NS1 mRNA, spliced NS2 mRNA and a spliced chimera mRNA from cloned influenza virus NS DNA in an SV40 vector. Virology 135, 139-147.

32. Shaw, M.W. and R.A. Lamb. (1984). A specific sub-set of host-cell mRNAs prime influenza virus mRNA synthesis. Virus Res. 1, 455-467.

33. Paterson, R.G., T.J.R. Harris and R.A. Lamb. (1984). Analysis and gene assignment of mRNAs of a paramyxovirus, simian virus 5. Virology 138, 310-323.

34. Paterson, R.G., T.J.R. Harris and R.A. Lamb. (1984). Fusion protein of the paramyxovirus simian virus 5: Nucleotide sequence of mRNA predicts a highly hydrophobic glycoprotein. Proc. Natl. Acad. Sci. USA 81, 6706-6710.

35. Hiebert, S.W., R.G. Paterson and R.A. Lamb. (1985). Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: Nucleotide sequence of the mRNA predicts an N-terminal membrane anchor. J. Virol. 54, 1-6.

36. Lamb, R.A., S.L. Zebedee and C.D. Richardson. (1985). Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40, 627-633.

37. Hiebert, S.W., R.G. Paterson and R.A. Lamb. (1985). Identification and predicted sequence of a previously unrecognized small hydrophobic protein, SH, of the paramyxovirus simian virus 5. J. Virol. 55, 744-751.

38. Zebedee, S.L., C.D. Richardson and R.A. Lamb. (1985). Characterization of the influenza virus M2 integral membrane protein and expression at the infected-cell surface from cloned cDNA. J. Virol. 56, 502-511.

39. Paterson, R.G., S.W. Hiebert and R.A. Lamb. (1985). Expression at the cell surface of biologically active fusion and hemagglutinin-neuraminidase proteins of the paramyxovirus SV5 from cloned cDNA. Proc. Natl. Acad. Sci. USA 82, 7520-7524.

40. Nicholson, A.W., H.M. Frankfort, N.G. Davis, S. Ferrari, R.A. Lamb and H.D. Robertson. (1986). Direct characterization of influenza viral NS1 mRNA and related sequences from infected HeLa cells and a cell-free transcription system. Biochem. Biophys. Acta. 868, 153-163.

41. Hiebert, S.W., M.A. Williams and R.A. Lamb. (1986). Nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79: Maintenance of a second large open reading frame. Virology 155, 747-751.

42. Williams, M.A. and R.A. Lamb. (1986). Determination of the orientation of an integral membrane protein and sites of glycosylation by oligonucleotide-directed mutagenesis: Influenza B virus NB glycoprotein lacks a cleavable signal sequence and has an extracellular NH2-terminal region. Molec. Cell. Biol. 6, 4317-4328.

43. Paterson, R.G. and R.A. Lamb. (1987). Ability of the hydrophobic fusion related external domain of a paramyxovirus F protein to act as a membrane anchor. Cell 48, 441-452.

44. Paterson, R.G., R.A. Lamb, B. Moss and B.R. Murphy. (1987). Comparison of the relative roles of the F and HN surface glycoproteins of the paramyxovirus simian virus 5 in inducing protective immunity. J. Virol. 61, 1972-1977.

45. Williams, M.A. and R.A. Lamb. (1988). Polylactosaminoglycan modification of a small integral membrane glycoprotein, influenza B virus NB. Molec. Cell. Biol. 8, 1186-1196.

46. Hiebert, S.W., C.D. Richardson and R.A. Lamb. (1988). Cell surface expression and orientation in membranes of the 44 amino acid SH protein of simian virus 5. J. Virol. 62, 2347-2357.

47. Hull, J.D., R. Gilmore and R.A. Lamb. (1988). Integration of a small integral membrane protein, M2 of influenza virus, across the endoplasmic reticulum: Analysis of an internal combined signal sequence/stop transfer domain that confers an ectoplasmic NH2 terminus. J. Cell. Biol. 106, 1489-1498.

48. Zebedee, S.L. and R.A. Lamb. (1988). Influenza A virus M2 protein: Monoclonal restriction of virus growth and detection of M2 in virions. J. Virol. 62, 2762-2772.

49. Hiebert, S.W. and R.A. Lamb. (1988). Cell surface expression of glycosylated, non-glycosylated and non-native forms of a cytoplasmic protein pyruvate kinase. J. Cell. Biol. 107, 865-876.

50. Thomas, S.M., R.A. Lamb and R.G. Paterson. (1988). Two mRNAs that differ by two non-templated nucleotides encode the amino co-terminal proteins P and V of the paramyxovirus SV5. Cell 54, 891-902.

51. Williams, M.A. and R.A. Lamb. (1989). Effect of mutations and deletions in a bicistronic mRNA on the synthesis of influenza B virus NB and NA glycoproteins. J. Virol. 63, 28-35.

52. Paterson, R.G., M.A. Shaughnessy and R.A. Lamb. (1989). Analysis of the relationship between cleavability of a paramyxovirus fusion protein and length of the connecting peptide. J. Virol. 63, 1293-1301.

53. Zebedee, S.L. and R.A. Lamb. (1989). Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein. Proc. Natl. Acad Sci. USA 86, 1061-1065.

54. Lamb, R.A. and G. Dreyfuss. (1989). Unwinding with a vengeance. (Newsand Views). Nature (Lond). 337, 19-20.

55. Zebedee, S.L. and R.A. Lamb. (1989). Nucleotide sequences of influenza A virus RNA segment 7: A comparison of five isolates. Nucl. Acids Res. 17, 2870.

56. Parks, G.D., J.D. Hull and R.A. Lamb. (1989). Transposition of domains between the M2 and HN viral membrane proteins results in polypeptides which can adopt more than one membrane orientation. J. Cell Biol. 109, 2023-2032.

57. Ng, D.T.W., R.E. Randall and R.A. Lamb. (1989). Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin-neuraminidase: Specific and transient association with GRP78-BiP in the ER and extensive internalization from the cell surface. J. Cell Biol. 109, 3273-3289.

1990-1999 -back to top

58. Treanor, J.J., E.L. Tierney, S.L. Zebedee, R.A. Lamb and B.R. Murphy. (1990). Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice. J. Virol. 64, 1375-1377.

59. Paterson, R.G. and R.A. Lamb. (1990). Conversion of a class II integral membrane protein into a soluble and efficiently secreted protein: Multiple intracellular and extracellular oligomeric and conformational forms. J. Cell Biol. 110, 999-1011.

60. Ng, D.T.W., S.W. Hiebert and R.A. Lamb. (1990). Different roles of individual N-linked oligosaccharide chains in the folding, assembly, and transport of the simian virus 5 hemagglutinin-neuraminidase. Molec. Cell. Biol. 10, 1989-2001.

61. Sheshberadaran, H. and R.A. Lamb. (1990). Sequence characterization of the membrane protein of the paramyxovirus simian virus 5. Virology 176, 234-243.

62. Parks, G.D. and R.A. Lamb. (1990). Defective assembly and intracellular transport of mutant paramyxovirus hemagglutinin-neuraminidase proteins containing altered cytoplasmic domains. J. Virol. 64, 3605-3616.

63. Paterson, R.G. and R.A. Lamb. (1990). RNA editing by G nucleotide insertion in mumps virus "P" gene mRNA transcripts. J. Virol. 64, 4137-4145.

64. Horvath, C.M., M.A. Williams and R.A. Lamb. (1990). Eukaryotic coupled translation of tandem cistrons: Identification of the influenza B virus BM2 polypeptide. EMBO J. 9, 2639-2647.

65. Parks, G.D. and R.A. Lamb. (1990). Folding and oligomerization properties of a soluble and secreted form of the paramyxovirus hemagglutinin-neuraminidase glycoprotein. Virology 178, 498-508.

66. Parks, G.D. and R.A. Lamb. (1991). Topology of eukaryotic type II membrane proteins: Importance of N-terminal positively charged residues flanking the hydrophobic domain. Cell 64, 777-787.

67. Watowich, S.S., R.I. Morimoto and R.A. Lamb. (1991). Flux of the paramyxovirus hemagglutinin-neuraminidase through the endoplasmic reticulum activates transcription of the GRP78-BiP gene. J. Virol. 65, 3590-3597.

68. Lamb, R.A. and C.M. Horvath. (1991). Diversity of coding strategies in influenza viruses. Trends Genet. 7, 261-266.

69. Holsinger, L.J. and R.A. Lamb. (1991). Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds. Virology 183, 32-43.

70. Sheshberadaran, H. and R.A. Lamb. (1991). Simian virus 5 membrane protein maturation: Expression in virus-infected cells and from a eukaryotic vector. Virology 183, 803-809.

71. Simpson, D.A. and R.A. Lamb. (1991). Influenza virus ts61S hemagglutinin is significantly defective in polypeptide folding and intracellular transport at the permissive temperature. Virology 185, 477-483.

72. Simpson, D.A. and R.A. Lamb. (1992). Alterations to influenza virus hemagglutinin cytoplasmic tail modulate virus infectivity. J. Virol. 66, 790-803.

73. Ng, D.T.W., S.S. Watowich and R.A. Lamb. (1992). Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene. Molec. Biol. Cell 3, 143-155.

74. Parks, G.D., C.D. Ward and R.A. Lamb. (1992). Molecular cloning of the NP and L genes of simian virus 5: Identification of highly conserved domains in paramyxovirus NP and L proteins. Virus Res. 22, 259-279.

75. Horvath, C.M. and R.A. Lamb. (1992). Studies on the fusion peptide of a paramyxovirus fusion glycoprotein: Roles of the conserved residues in cell fusion. J. Virol. 66, 2443-2455.

76. Pinto, L.H., L.J. Holsinger and R.A. Lamb. (1992). Influenza virus M2 protein has ion channel activity. Cell 69, 517-528.

77. Horvath, C.M., R.G. Paterson, M.A. Shaughnessy, R. Wood and R.A. Lamb. (1992). Biological activity of paramyxovirus fusion proteins: Factors influencing formation of syncytia. J. Virol. 66, 4564-4569.

78. Hughey, P.G., R.W. Compans, S.L. Zebedee and R.A. Lamb. (1992). Expression of the influenza A virus M2 protein is restricted to apical surfaces of polarized epithelial cells. J. Virol. 66, 5542-5552.

79. Doms, R.W., R.A. Lamb, J.K. Rose and A. Helenius. (1993). Folding and assembly of viral membrane proteins. Virology 193, 545-562.

80. Parks, G.D. and R.A. Lamb. (1993). Role of N-terminal charged residues in establishing membrane protein topology. J. Biol. Chem. 268, 19101-19109.

81. Wang, C., K. Takeuchi, L.H. Pinto and R.A. Lamb. (1993). The ion channel activity of influenza A virus M2 protein: Characterization of the amantadine block. J. Virol. 67, 5585-5594.

82. Lamb, R.A. (1993). Paramyxovirus fusion: A hypothesis for changes. Virology 197, 1-11. 81.

83. Takeuchi, K. and R.A. Lamb. (1994). Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport. J. Virol. 68, 911-919.

84. Russell, R., R.G. Paterson and R.A. Lamb. (1994). Studies with cross-linking reagents on the oligomeric form of the paramyxovirus fusion protein. Virology 199, 160-168.

85. Holsinger, L.J., D. Nichani, L.H. Pinto and R.A. Lamb. (1994). Influenza A virus M2 ion channel protein: A structure-function analysis. J. Virol. 68, 1551-1563.

86. Takeuchi, K., M.A. Shaughnessy and R.A. Lamb. (1994). Influenza virus M2 protein ion channel activity is not required to maintain the equine-1 hemagglutinin in its native form in infected cells. Virology 202, 1007-1011.

87. Tosteson, M.T., L.H. Pinto, L.J. Holsinger and R.A. Lamb. (1994). Reconstitution of the influenza virus M2 ion channel in lipid bilayers. J. Membr. Biol. 142, 117-126.

88. Wang, C., R.A. Lamb and L.H. Pinto. (1994). Direct measurement of the influenza A virus M2 protein ion channel activity in mammalian cells. Virology 205, 133-140.

89. Jin, H., G.P. Leser and R.A. Lamb. (1994). The influenza virus hemagglutinin cytoplasmic tail is not essential for virus assembly or infectivity. EMBO J. 13, 5504-5515.

90. Holsinger, L.J., M.A. Shaughnessy, A. Micko, L.H. Pinto and R.A. Lamb. (1995). Analysis of the post-translational modifications of the influenza virus M2 protein. J. Virol. 69, 1219-1225.

91. Paterson, R.G., G.P. Leser, M.A. Shaughnessy and R.A. Lamb. (1995). The paramyxovirus SV5 V protein binds two atoms of zinc and is a structural component of virions. Virology 208, 121-131.

92. Ward, C.D., R.G. Paterson and R.A. Lamb. (1995). Mutants of the paramyxovirus SV5 fusion protein: Regulated and extensive syncytium formation. Virology 209, 242-249.

93. Bagai, S. and R.A. Lamb. (1995). Individual roles of N-linked oligosaccharide chains in intracellular transport of the paramyxovirus SV5 fusion protein. Virology 209, 250-256.

94. Schneemann, A., P.A. Schneider, R.A. Lamb and W.I. Lipkin. (1995). The remarkable coding strategy of Borna disease virus: A new member of the nonsegmented negative strand RNA viruses. Virology 210, 1-8.

95. Pinto, L.H. and R.A. Lamb. (1995). Understanding the mechanism of action of the anti-influenza drug amantadine. Trends Microbiol. 3, 271.

96. Kimberlin, D.W., D.M. Coen, K.K. Biron, J.I. Cohen, R.A. Lamb, M. McKinlay, E.A. Emini and R.J. Whitley. (1995). Molecular mechanisms of antiviral resistance. Antiviral Res. 26, 369-401.

97. Wang, C., R.A. Lamb and L.H. Pinto. (1995). Activation of the M2 ion channel of influenza virus: A role for the transmembrane domain histidine residue. Biophys J. 69, 1363-1371.

98. Hughey, P.G., P.C. Roberts, L.J. Holsinger, S.L. Zebedee, R.A. Lamb and R.W. Compans. (1995). Effects of antibody to the influenza A virus M2 protein on M2 surface expression and virus assembly. Virology 212, 411-421.

99. Bagai, S. and R.A. Lamb. (1995). Quantitative measurement of paramyxovirus fusion: Differences in requirements of glycoproteins between simian virus 5 and human parainfluenza virus 3 or Newcastle disease virus. J. Virol. 69, 6712-6719.

100. Shimbo, K., D.L. Brassard, R.A. Lamb and L.H. Pinto. (1995). Viral and cellular small integral membrane proteins can modify ion channels endogenous to Xenopus oocytes. Biophys. J. 69, 1819-1829.

101. Leser, G.P., K.J. Ector and R.A. Lamb. (1996). The paramyxovirus SV5 HN glycoprotein but not the F glycoprotein, is internalized via coated pits and enters the endocytic pathway. Mol. Biol. Cell 7, 155-172.

102. Jin, H., K. Subbarao, S. Bagai, G.P. Leser, B.R. Murphy and R.A. Lamb. (1996). Palmitylation of the influenza virus hemagglutinin (H3) is not essential for virus assembly or infectivity. J. Virol. 70, 1406-1414.

103. Brassard, D.L., Leser, G.P. and R.A. Lamb. (1996). Influenza B virus NB glycoprotein is a component of the virion. Virology 220, 350-360.

104. Sakaguchi, T., G.P. Leser and R.A. Lamb. (1996). The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus. J. Cell Biol. 133, 733-747.

105. Shimbo, K., D.L. Brassard, R.A. Lamb and L.H. Pinto. (1996). Ion selectivity and activation of the M2 ion channel of influenza virus. Biophys. J. 70,1335-1346.

106. Tu, Q., L.H. Pinto, G. Luo, M.A. Shaughnessy, D. Mullaney, S. Kurtz, M. Krystal and R.A. Lamb. (1996). Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus. J. Virol. 70, 4246-4252.

107. Bagai, S. and R.A. Lamb. (1996). Truncation of the C-terminal region of the paramyxovirus SV5 fusion protein leads to hemifusion but not complete fusion. J. Cell Biol. 135, 73-84.

108. Zhang, J. and R.A. Lamb. (1996). Characterization of the membrane association of the influenza virus matrix protein in living cells. Virology 225, 255-265.

109. Lamb, R.A. and L.H. Pinto. (1997). Do Vpu and Vpr of human immunodeficiency virus type 1 and NB of influenza B virus have ion channel activities in the viral life cycles? Virology 229, 1-11.

110. Jin, H., G.P. Leser, J. Zhang and R.A. Lamb. (1997). Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape. EMBO J. 16, 1236-1247.

111. Sakaguchi, T., Q. Tu, L.H. Pinto and R.A. Lamb. (1997). The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer. Proc. Natl. Acad. Sci. (USA) 94, 5000-5005.

112. Melikyan, G.B., H. Jin, R.A. Lamb and F.S. Cohen. (1997). The role of the cytoplasmic tail region of influenza virus hemagglutinin in formation and growth of fusion pores. Virology 235, 118-128.

113. Brassard, D.L. and R.A. Lamb. (1997). Expression of influenza B virus hemagglutinin containing multibasic residue cleavage sites. Virology 236, 234-248.

114. Paterson, R.G., M.L. Johnson and R.A. Lamb. (1997). Paramyxovirus fusion (F) protein and hemagglutinin-neuraminidase (HN) protein interactions: Intracellular retention of F and HN does not affect transport of the homotypic HN or F protein. Virology 237, 1-9.

115. Pinto, L.H., G.R Dieckmann, C.S. Gandhi, M.A. Shaughnessy, C.G. Papworth, J. Braman, J.D. Lear, R.A. Lamb and W.F. DeGrado. (1997). A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion-selectivity. Proc. Natl. Acad. Sci. (USA) 94, 11301-11306.

116. He, B., R.G. Paterson, C.D. Ward and R.A. Lamb. (1997). Recovery of infectious SV5 from cloned DNA and expression of a foreign gene. Virology 237, 249-260.

117. Pekosz, A. and R.A. Lamb. (1997). The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins. Virology 237, 439-451.

118. Huang, X.F., R.W. Compans, S. Chen, R.A. Lamb and P. Arvan. (1997). Polarized apical targeting directed by the signal/anchor region of simian virus 5 hemagglutinin-neuraminidase. J. Biol. Chem. 272, 27598-27604.

119. Bagai, S. and R.A. Lamb. (1997). A glycine to alanine substitution in the paramyxovirus SV5 fusion peptide increases the initial rate of fusion. Virology 238, 283-290.

120. Lin, G.Y., R.G. Paterson and R.A. Lamb. (1997). The RNA binding region of the paramyxovirus SV5 V and P proteins. Virology 238, 460-469.

121. Zhou, J., R.E. Dutch and R.A. Lamb. (1997). Proper spacing between heptad repeat B and the transmembrane domain boundary of the paramyxovirus SV5 F protein is critical for biological activity. Virology 239, 327-339.

122. Roberts, P.C., R.A. Lamb and R.W. Compans. (1998). The M1 and M2 proteins of influenza A virus are important determinants in filamentous particle formation. Virology 240, 127-137.

123. Joshi, S.B., R.E. Dutch and R.A. Lamb. (1998). A core trimer of the paramyxovirus fusion protein: Parallels to influenza virus hemagglutinin and HIV-1 gp41. Virology 248, 20-34.

124. Dutch, R.E., S.B. Joshi and R.A. Lamb. (1998). Membrane fusion promoted by increasing surface densities of the paramyxovirus F and HN proteins: Comparison of fusion reactions mediated by simian virus 5 F, human parainfluenza virus 3 F and influenza virus HA. J. Virol. 72, 7745-7753.

125. Lin, G.Y., R.G. Paterson, C.D. Richardson and R.A. Lamb. (1998). The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein. Virology 249, 189-200.

126. He, B., G.P. Leser, R.G. Paterson and R.A. Lamb. (1998). The paramyxovirus SV5 small hydrophobic (SH) protein is not essential for virus growth in tissue culture cells. Virology 250, 30-40.

127. Pekosz, A. and R.A. Lamb. (1998). Influenza C virus CM2 integral membrane glycoprotein is produced from a polypeptide precursor by cleavage of an internal signal peptide. Proc. Natl. Acad. Sci. USA 95, 13233-13238.

128. Lamb, R.A., S.B. Joshi and R.E. Dutch. (1999). The paramyxovirus fusion protein forms an extremely stable core trimer: Structural parallels to influenza virus hemagglutinin and HIV gp41. Molec. Membrane Biol. 16, 11-19.

129. Gandhi, C.S., K. Shuck, J.D. Lear, G.R. Dieckmann, W.F. DeGrado, R.A. Lamb and L.H. Pinto. (1999). Cu(II) inhibition of the proton translocation machineryof the influenza A virus M2 protein. J. Biol. Chem. 274, 5474-5482.

130. Dutch, R.E., G.P. Leser and R.A. Lamb. (1999). Paramyxovirus fusion protein: Characterization of the core trimer, a rod-shaped complex with helices in anti-parallel orientation. Virology 254, 147-159.

131. Bauer, C.M., T.A. Cross, L.H. Pinto and R.A. Lamb. (1999). The influenza virus M2 ion channel protein: Probing the structure of the transmembrane domain in intact cells by using engineered disulfide cross-linking. Virology 254, 196-209.

132. Baker, K.A., R.E. Dutch, R.A. Lamb and T.S. Jardetzky. (1999). Structural basis for paramyxovirus-mediated membrane fusion. Molec. Cell 3, 309-319.

133. He, B. and R.A. Lamb. (1999). Effect of inserting paramyxovirus simian virus 5 gene junctions at the HN/L gene junction: Analysis of accumulation of mRNAs transcribed from rescued viable viruses. J. Virol. 73, 6228-6234.

134. Pekosz A., B. He, and R.A. Lamb. (1999). Reverse genetics of negative-strand RNA viruses: closing the circle. Proc. Natl. Acad. Sci. (USA) 96, 8804-8806.

135. Leser, G.P., K.J. Ector, D.T.W. Ng, M.A. Shaughnessy, and R.A. Lamb. (1999). The signal for clathrin-mediated endocytosis of the paramyxovirus SV5 HN protein resides at the transmembrane domain-ectodomain boundary region. Virology 262, 79-92.

136. Schmitt, A.P., B. He and R.A. Lamb. (1999). Involvement of the cytoplasmic domain of the hemagglutinin-neuraminidase protein in assembly of the paramyxovirus simian virus 5. J. Virol. 73, 8703-8712.

137. Pekosz, A. and R.A. Lamb. (1999). Cell surface expression of biologically active influenza C virus HEF glycoprotein expressed from cDNA. J. Virol. 73, 8808-8812.

138. Tobler, K., M.L. Kelly, L.H. Pinto, and R.A. Lamb. (1999). Effect of cytoplasmic tail truncations on the activity of the M2 ion channel of influenza A virus. J. Virol. 73, 9695-9701.

2000-2004-back to top

139. Mould, J.A., H.-C. Li, C.S. Dudlak, J.D. Lear, A. Pekosz, R.A. Lamb and L.H. Pinto. (2000). Mechanism for proton conduction of the M2 ion channel of influenza A virus. J. Biol. Chem. 275, 8592-8599.

140. Zhang, J., G.P. Leser, A. Pekosz and R.A. Lamb. (2000). The cytoplasmic tails of the influenza virus spike glycoproteins are required for normal genome packaging. Virology 269, 325-334.

141. Zhang, J., A. Pekosz and R.A. Lamb. (2000). Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins. J. Virol. 74, 4634-4644.

142. Paterson, R.G., C.J. Russell and R.A. Lamb. (2000). Fusion protein of the paramyxovirus SV5: Destabilizing and stabilizing mutants of fusion activation. Virology 270, 17-30.

143. Shuck, K., R.A. Lamb, and L.H. Pinto. (2000). Analysis of the pore structure of the influenza A virus M2 ion channel by the substituted- cysteine accessibility method. J. Virol. 74, 7755-7761.

144. Lin, G.Y. and R.A. Lamb. (2000). The paramyxovirus simian virus 5 V protein slows progression of the cell cycle. J. Virol. 74, 9152-9166.

145. Mould, J.A., J.E. Drury, S. M. Frings, U.B. Kaupp, A. Pekosz, R.A. Lamb, and L.H. Pinto. (2000). Permeation and activation of the M2 ion channel of influenza A virus. J. Biol. Chem. 275, 31038-31050.

146. Pekosz, A. and R.A. Lamb. (2000). Identification of a membrane targeting and degradation signal in p42 of influenza C virus. J. Virol. 74, 10480-10488.

147. Dutch, R.E., T.S. Jardetzky, and R.A. Lamb. (2001). Virus membrane fusion proteins: biological machines that undergo a metamorphosis. BioScience Reports 20, 597-612.

148. Young, D.F., N. Chatziandreou, B. He, S. Goodbourn, R.A. Lamb and R.E. Randall. (2001). Single amino acid substitution in the V protein of simian virus 5 differentiates its ability to block interferon signalling in human and murine cells. J. Virol. 75, 3363-3370.

149. He, B., G.Y. Lin, J.E. Durbin, R.K. Durbin and R.A. Lamb. (2001). The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells. J. Virol. 75, 4068-4079.

150. Dutch, R.E., R.N. Hagglund, M.A. Nagel, R.G. Paterson and R.A. Lamb. (2001). Paramyxovirus fusion (F) protein: A conformational change on cleavage activation. Virology 281, 138-150.

151. Parisien, J.-P., J.F. Lau, J.J. Rodriguez, B.M., Sullivan, A. Moscona, G.D. Parks, R.A. Lamb and C.M. Horvath. (2001). The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2. Virology 283, 230-239.

152. Dutch, R.E. and R.A. Lamb. (2001). Deletion of the cytoplasmic tail of the fusion protein of the paramyxovirus simian virus 5 affects fusion pore enlargement. J. Virol. 75, 5363-5369.

153. Russell, C.J., T.S. Jardetzky and R.A. Lamb. (2001). Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion. EMBO J. 20, 4024-4034.

154. Lamb, R.A. and M. Takeda. (2001). Death by influenza virus protein. (News and Views) Nature Medicine 7, 1286-1288.

155. Takeda, M., A. Pekosz, K. Shuck, L.H. Pinto, and R.A. Lamb. (2002). Influenza A virus M2 ion channel activity is essential for efficient replication in tissue culture. J. Virol. 76, 1391-1399.

156. Schmitt, A.P., G.P. Leser, D.L. Waning and R.A. Lamb. (2002). Requirements for budding of paramyxovirus simian virus 5 virus-like particles. J. Virol. 76, 3952-3964.

157. Tang, T., F. Zaitseva, R.A. Lamb and L.H. Pinto. (2002). The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue. J. Biol. Chem. 277, 39880-39886.

158. Waning, D.L., A.P. Schmitt, G.P. Leser, and R.A. Lamb. (2002). Roles for the cytoplasmic tails of the fusion (F) and hemagglutinin-neuraminidase (HN) proteins in budding of the paramyxovirus simian virus 5. J. Virol. 76, 9284-9297.

159. He, B., R.G. Paterson, N. Stock, J.E. Durbin, R.K. Durbin, S. Goodbourn, R.E. Randall and R.A. Lamb. (2002). Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: The multifunctional V protein blocks both interferon-_ induction and interferon signalling. Virology 303, 15-32.

160. Poole, E. B. He, R.A. Lamb, R.E. Randall and S. Goodbourn. (2002). The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta. Virology 303, 33-46.

161. Tian, C., K. Tobler, R.A. Lamb, L.H. Pinto, and T.A. Cross. (2002). Expression and initial structural insights from solid-state NMR of the M2 proton channel from influenza A virus. Biochemistry 41, 11294-11300.

162. Young, D.F., L. Andrejeva, A. Livingstone, S. Goodbourn, R.A. Lamb, P.L. Collins, R.M. Elliott and R.E. Randall. (2003). Virus replication in engineered human cells that do not respond to interferons. J. Virol. 77, 2174-2181.

163. Paterson, R.G., M. Takeda, Y. Ohigashi, L.H. Pinto and R. A. Lamb. (2003). Influenza B virus BM2 protein is an oligomeric integral membrane protein expressed at the cell surface. Virology 306, 7-17.

164. Mould, J.A., R.G. Paterson, M. Takeda, Y. Ohigashi, P. Venkataraman, R.A. Lamb and L.H. Pinto. (2003). Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes. Dev. Cell 5, 175-184.

165. Russell, C.J., K.L. Kantor, T.S. Jardetzky and R.A. Lamb. (2003). A dual- functional paramyxovirus F protein regulatory switch segment: activation and membrane fusion. J. Cell Biol. 163, 363-374.

166. Takeda, M., G.P. Leser, C.J. Russell and R.A. Lamb. (2003). Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion. Proc. Natl. Acad. Sci USA 100, 14610-14617.

167. Tian, C., P.F. Gao, L.H. Pinto, R.A. Lamb and T.A. Cross. (2003). Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers. Protein Sci. 12, 2597-2605.

168. Jardetzky, T.S. and R.A. Lamb. (2004). A class act. Nature 427, 307-308.

169. Pinto, L.H. and R.A. Lamb. (2004). Viral ion channels as models for ion transport and targets for antiviral drug action. FEBS Lett. 560, 1-2.

170. Sun, M., T.A. Rothermel, L. Shuman, J.A. Aligo, S. Xu, Y. Lin, R.A. Lamb and B. He. (2004). Conserved cysteine-rich domain of paramyxovirus simian virus 5 V protein plays an important role in blocking apoptosis. J. Virol. 78, 5068-5078.

171. Waning, D.L., C.J. Russell, T.S. Jardetzky, and R.A. Lamb. (2004). Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail. Proc. Natl. Acad. Sci. (USA) 101, 9217-9222.

172. Schmitt, A.P. and R.A. Lamb. (2004). Escaping from the cell: assembly and budding of negative-strand RNA viruses. Curr. Top. Microbiol. Immunol. 283, 145-196.

173. Russell, C.J., T.S. Jardetzky and R.A. Lamb. (2004). Conserved glycine residues in the fusion peptide of the paramyxovirus fusion (F) protein regulate activation of the native state. J. Virol. 78, 13727-13742.

2005-back to top

174. Schmitt, A.P., G.P. Leser, E. Morita, W.I. Sundquist and R.A. Lamb. (2005). Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus. J. Virol. 79, 2988-2997.

175. Venkataraman, P., R.A. Lamb and L.H. Pinto. (2005). Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus. J. Biol. Chem. 22, 21463-21472 .

176. Yuan, P., T. Thompson, B.A. Wurzburg, R.G. Paterson, R.A. Lamb and T.S. Jardtezky. (2005). Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, siallylactose. Structure 13, 803-815.

177. Yin, H.S., R.G. Paterson, X. Wen, R.A. Lamb, and T.S. Jardetzky. (2005). Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein. Proc. Natl. Acad. Sci. USA 102, 9288-9293.

178. Schmitt, A.P. and R.A. Lamb. (2005). Influenza virus assembly and budding at the viral budozone. Adv. Virus. Res. 64, 383-416.

179. Chen, B.J., M. Takeda and R.A. Lamb. (2005). Influenza virus hemagglutinin (H3 subtype) requires palmitoylation of its cytoplasmic tail for assembly: M1 proteins of two subtypes differ in their ability to support assembly. J. Virol. 79, 13673-13684.

180. Leser, G.P. and R.A. Lamb. (2005). Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA, and M2 proteins. Virology 342, 215-227.

181. Lamb, R.A. and D. Jackson. (2005). Extinct 1918 virus comes alive. (News and Views) Nature Medicine 11, 1154-156.

2006-back to top

182. Lamb, R.A., R.G. Paterson and T.S. Jardetzky. (2006). Paramyxovirus membrane fusion: lessons from the F and HN atomic structures. Virology 344, 30-37.

183. Yin, H.S., R.G. Paterson, X. Wen, R.A. Lamb, and T.S. Jardetzky. (2006). Structure of the parainfluenza virus 5 F protein in its metastable, pre-fusion conformation. Nature 439, 38-44.

184. Pinto, L.H. and R.A. Lamb. (2006). The M2 protein channels of influenza A and B viruses.   J. Biol. Chem . 281, 8997-9000.

185. Bissonnette, M.L.Z., S.A. Connolly, D.F. Young, R.E. Randall, R.G. Paterson, and R.A. Lamb.   (2006). Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5.   J. Virol. 80, 3071-3077.

186. Pinto, L.H. and R.A. Lamb.   (2006).   Influenza virus proton channels.   Photochem. Photobiol. Sci. 5, 629-632.

187. Vega, R.A., D. Maspoch, C.K. Shen, J.J. Kakkassery, B.J. Chen, R.A. Lamb, and C.A. Mirkin.   (2006).   Functional antibody arrays through metal ion-affinity templates.   Chembiochem. 7, 1653-1657.

188. Connolly, S.A. and R.A. Lamb.   (2006).   Paramyxovirus fusion: real-time measurement of parainfluenza virus 5 virus-cell fusion. Virology 355, 203-212.

189. Hale, B.G., D. Jackson, Y-H. Chen, R.A. Lamb and R.E. Randall.   (2006).   Influenza A virus NS1 protein binds p85 b and activates phosphatidylinositol-3-kinase signaling.   Proc. Natl. Acad. Sci. USA 103, 14194-14199.

190. Connolly, S.A., G.P. Leser, H.S. Yin, T.S. Jardetzky and R.A. Lamb.   (2006).   Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy. Proc. Natl. Acad. Sci. USA. 103, 17903-17908. PMCID: PMC1635158

191. Pinto, L.H. and R.A. Lamb.   (2006).   Controlling influenza virus replication by inhibiting its proton channel.  Mol. BioSyst. 3, 18-23.

2007- back to top

192. Tompkins, S. M., Y. Lin, G.P. Leser, K.A. Kramer, D.L. Haas, E.W. Howerth, R.K. Durbin, J.E. Durbin, R. Tripp, R.A. Lamb and B. He.   (2007).   Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge.  Virology 362, 139-150.

193. Chen, B.J., G.P. Leser, E. Morita and R.A. Lamb.   (2007).   Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles.  J. Virol. 81, 7111-7123.

194. Lamb, R.A. and T.S. Jardetzky.   (2007).   Structural basis of viral invasion:   lessons from paramyxovirus F.  Curr. Opin. Struct. Biol. 17, 427-436.

195. Vega, R.A., C.K. Shen, D. Maspoch, J.G. Robach, R.A. Lamb and C.A. Mirkin.   (2007).   Monitoring single-cell infectivity with anti virus-particle nanoarrays fabricated by parallel dip-pen nanolithography.  Small., 3, 1482-1485.

196. Backovic M., G.P. Leser, R.A. Lamb, R. Longnecker and T.S. Jardetzky.   (2007).   Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins.  Virology, 368, 102-113.

2008- back to top

197. Chen, B.J. and R.A. Lamb.   (2007).   Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? Virology, 372, 221-232. PMCID: PMC2751282

198. Ballannik, V., R.A. Lamb and L.H. Pinto.   (2008).   The oligomeric state of the active BM2 ion channel protein of influenza B virus.  J. Biol. Chem. 283, 4895-4904.

199. Jackson, D., M.J. Hossain, D. Hickman, D.R. Perez and R.A. Lamb.   (2008).   A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc. Natl. Acad. Sci. USA 105, 4381-4386. PMCID: PMC2393797

200. Ma, C., C.S. Soto, Y. Ohigashi, A. Taylor, V. Bournas, B. Glawe, M.K. Udo, W.F. DeGrado, R.A. Lamb and L.H. Pinto.   (2008).   Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus. J. Biol. Chem. 283, 15921-15931. PMCID: PMC2414288

201. Stouffer, A.L., C. Ma, L. Cristian, Y. Ohigashi, R.A. Lamb, J.D. Lear, L.H. Pinto and W.F. DeGrado.   (2008).   The interplay of thermodynamic stability, functional tuning, and drug resistance in the evolution of the M2 proton channel from the influenza A virus. Structure 16, 1067-1076. PMCID: PMC2594009

202. Yuan, P., G.P. Leser, B. Demeler, R.A. Lamb and T.S. Jardetzky.   (2008).   Domain architecture and oligomerization properties of the paramyxovirus PIV5 hemagglutinin-neuraminidase (HN) protein.  Virology 378, 282-291. PMCID: PMC2603141

203. Jing, X., C. Ma, Y. Ohigashi, F.A. Oliveira, T.S. Jardetzky, L.H. Pinto and R.A. Lamb.   (2008).   Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel.  Proc. Natl. Acad. Sci. USA 105, 10967-10972. PMCID: PMC2492755

204. Chen, B.J., G.P. Leser, D. Jackson and R.A. Lamb.   (2008).   The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding.   J. Virol. 82, 10059-10070. PMCID: PMC2566248

205. Jackson, D. and R.A. Lamb.   (2008).   The influenza A virus spliced messenger RNA M mRNA3 is not required for viral replication in tissue culture.   J. Gen Virol. 89, 3097-3101.

2009- back to top

206. Bissonnette, M.L., J.E. Donald, W.F. DeGrado, T.S. Jardetzky and R.A. Lamb.   (2009).   Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion.   J. Mol. Biol. 386, 14-36. PMCID: PMC2750892

207. Ma, C., A.L. Polishchuk, Y. Ohigashi, A.L. Stouffer, A. Schön, E. Magavern, X. Jing, J.D. Lear, E. Freire, R.A. Lamb, W.F. DeGrado and L.H. Pinto.   (2009).   Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel.   Proc. Natl. Acad. Sci. USA 106, 12283-12288.   PMCID: PMC2718339

208. Connolly, S.A., G.P. Leser, T.S. Jardetzky and R.A. Lamb. (2009).   Bimolecular complementation of paramyxovirus fusion (F) and hemagglutinin-neuraminidase (HN) proteins enhances fusion: implications for the mechanism of fusion triggering.   J. Virol. 83, 10857-10868. PMCID: PMC2772755

209. Rossman, J.S. and R.A. Lamb. (2009). Autophagy, apoptosis, and the influenza virus M2 protein.  Cell Host & Microbe 6, 299-300.

210. Ohigashi, Y., C. Ma, X. Jing, V. Balannick, L.H. Pinto and R.A. Lamb.  (2009).   An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition.   Proc. Natl. Acad. Sci. USA 106, 18775-18779.PMCID: PMC2774021

211. Balannik, V., J. Wang, Y. Ohigashi, X. Jing, E. Magavern, R.A. Lamb, W.F. DeGrado and L.H. Pinto. (2009). Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus. Biochemistry 48, 11872-11882. PMID: PMC2794939

2010- back to top

212. Balannik, V., V. Carnevale, G. Fiorin, B.G. Levine, R.A. Lamb, M.L. Klein, W.F. De Grado and L.H. Pinto. (2010). Functional studies and modeling of pore-lining residue mutants of the influenza A virus M2 ion channel. Biochemistry 49, 696-708.

213. Rossman, J.S. and R.A. Lamb. (2010). Swine-origin influenza virus and the 2009 pandemic. Am. J. Respir. Crit. Care Med. 181, 295-296.

214. Rossman, J.S., X. Jing, G.P. Leser, V. Balannik, L.H. Pinto and R.A. Lamb. (2010). Influenza virus M2 ion channel protein is necessary for filamentous virion formation. J. Virol. 84, 5078-5088. PMCID: PMC2863831

215. Swanson, K., X. Wen, G.P. Leser, R.G. Paterson, R.A. Lamb and T.S. Jardetzky. (2010). Structure of the Newcastle disease virus F protein in the post-fusion conformation. Virology 402, 372-379. PMCID: PMC2877518

216. Watanabe, R. and R.A. Lamb. (2010). Influenza virus budding does not require a functional AAA+ ATPase, VPS4. Virus Research 153, 58-63. PMCID: PMC3059594

217. Ravid, D., G.P. Leser and R.A. Lamb. (2010). A role of caveolin 1 in assembly and budding of the paramyxovirus parainfluenza virus 5. J. Virol. 84, 9749-9759. PMCID: PMC2937824

218. Robach, J.G. and R.A. Lamb. (2010). Analysis of parainfluenza virus-5 hemagglutinin-neuraminidase protein mutants that are blocked in internalization and degradation. Virology 406, 189-201. PMCID: PMC3059592

219. Acharya, R., V. Carnevale, G. Fiorin, B.G. Levine, A.L. Polishchuk, V. Balannik, I. Samish, R.A. Lamb, L.H. Pinto, W.F. DeGrado and M.L. Klein. (2010). Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc. Natl. Acad. Sci. USA 107, 15075-15080. PMCID: PMC2930543

220. Rossman, J.R., X. Jing, G.P. Leser and R.A. Lamb. (2010). Influenza virus M2 protein mediates ESCRT-independent membrane scission. Cell 142, 902-913. PMCID: PMC3059587

221. Polishchuk, A.L., J.D. Lear, C. Ma, R.A. Lamb, L.H. Pinto and W.F. DeGrado. (2010). A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein. Biochemistry 49, 10061-10071. PMCID: PMC3164293

2011- back to top

222. Park, M., H. Matsuura, R.A. Lamb, A.E. Barron and T.S. Jardetzky. (2011). A fluorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform. Anal. Biochem. 409, 195-201. PMCID: PMC3462168

223. Rossman, J.S. and R.A. Lamb. (2011). Influenza virus assembly and budding. Virology 411, 229-236. PMCID: PMC3086653

224. Duque, M.D., C. Ma, J. Wang, L. Naesens, J. Juárez-Jiménez, P. Camps, F.J. Luque, W.F. Degrado, R.A. Lamb, L.H. Pinto, and S. Vásquez. (2011). Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus. J. Med. Chem. 54, 2646-2657. PMCID: PMC3174104

225. Watanabe, R., G.P. Leser and R.A. Lamb. (2011). Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin. Virology 417, 50-56

226. Wang, J., C. Ma, V. Balannik, L.H. Pinto, R.A. Lamb and W.F. DeGrado. (2011). Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus. ACS Med. Chem. Lett. 2, 307-312. PMCID: PMC3116712

227. Wang, J., C. Ma, G. Fiorin, V. Carnevale, T. Wang, F. Hu, R.A. Lamb, L.H. Pinto, M. Hong, M.L. Klein and W.F. DeGrado. (2011). Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J. Am. Chem. Soc. 133, 12834-12841. PMCID: PMC3354620

228. Wang, J., C. Ma, Y. Wu, R.A. Lamb, L.H. Pinto and W.F. DeGrado. (2011). Exploring organosilane amines as potent inhibitors and structural probes of influenza A virus M2 proton channel. J. Am. Chem. Soc. 133, 13844-13847. PMCID: PMC3166227

229. Yuan, P., K.A. Swanson, G.P. Leser, R.G. Paterson, R.A. Lamb and T.S. Jardetzky. (2011). Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk. Proc. Nat. Acad. Sci. USA 108, 14920-14925. PMCID: PMC3169104

230. Zhang, L., P.L. Collins, R.A. Lamb and R.J. Pickles. (2011). Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus. Virology 421, 67-77. PMCID: PMC3208758

231. Bose, S.*, B.D. Welch*, C.A. Kors, P. Yuan, T.S. Jardetzky and R.A. Lamb. (2011). Structure and mutagenesis of the parainfluenza virus 5 hemagglutintin-neuraminidase stalk domain reveals a four-helix bundle and the role of the stalk in fusion promotion. J. Virol. 85, 12855-12866. PMCID: PMC3233124

232. Kim, Y.H., J.E. Donald, G. Grigoryan, G.P. Leser, A.Y. Fadeev, R.A. Lamb and W.F. DeGrado. (2011). Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5. Proc. Natl. Acad. Sci. USA 108, 20992-20997. PMCID: PMC3248524

2012-back to top

233. Zokarkar, A. and R.A. Lamb. (2012). The paramyxovirus fusion (F) protein C-terminal region: mutagenesis indicates an indivisible protein unit. J. Virol. 86, 2600-2609. PMCID: PMC3302293

234. Wen, X., J.C. Krause, G.P. Leser, R.G. Cox, R.A. Lamb, J. Williams, J.E. Crowe, Jr. and T.S. Jardetzky. (2012). Structure of the human metapneumovirus fusion protein in complex with a neutralizing antibody identifies a novel pneumovirus antigenic site. Nat. Struct. Molec. Biol. 19, 461-463. PMCID:PMC3546531

235. Yuan, P.*, R.G. Paterson*, G.P. Leser, R.A. Lamb and T.S. Jardetzky. (2012). Structure of the Ulster strain Newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence. PLoS Pathog. 8, e1002855, *co-equal authors. PMCID: PMC3415446

236. Rossman, J.S., G.P. Leser and R.A. Lamb. (2012). Filamentous influenza virus enters cells via macropinocytosis. J. Virol. 86, 10950-10960. PMCID:PMC3457176

237. Welch, B.D., Y. Liu, C.A. Kors, G.P. Leser, T.S. Jardetzky and R.A. Lamb. (2012). Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein. Proc. Natl. Acad. Sci. USA 109, 16672-16677.
Commentary, Proc. Natl. Acad. Sci. USA (2012) 109, 16404-16405. PMCID: PMC3478641

238. Bose, S., A. Zokarkar, B.D. Welch, G.P. Leser, T.S. Jardetzky and R.A. Lamb. (2012). Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering. Proc. Natl. Acad. Sci. USA 109, E2525-E2634. PMCID: PMC3465404

239. Zokarkar, A., S.A. Connolly, T.S. Jardetzky and R.A. Lamb. (2012). Reversible inhibition of fusion activity of a paramyxovirus fusion (F) protein by an engineered disulfide bond in the membrane proximal external region. J. Virol. 86, 12397-12401. PMCID: PMC3486459

2013-back to top

240. Wang, J., C. Ma, G. Fiorin, J. Wang, L.H. Pinto, R.A. Lamb, M.L. Klein and W.F. DeGrado. (2013). Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proc. Natl. Acad. Sci. USA 110, 1315-1320. PMCID: PMC3557100

241. Balgi, A.D., J. Wang, D.Y.H. Cheng, C. Ma, T.A. Pfeifer, Y. Shimizu, H.J. Anderson, L.H. Pinto, R.A. Lamb, W.F. DeGrado and M. Roberge. (2013). Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay. PLoS One 8, e55271. PMCID: PMC3562233

242. Wang, J., C. Ma, J. Wang, H. Jo, B. Canturk, G. Fiorin, L.H. Pinto, R.A. Lamb, M.L. Klein and W.F. DeGrado. (2013). Discovery of novel dual inhibitors of wild-type and the most prevalent drug-resistant mutant, S31N, of M2 proton channel from influenza A virus. J. Med. Chem. 56, 2804-2812. PMCID: PMC4036227

243. Lamb, R.A. (2013). Deadly H7N9 influenza virus: a pandemic in the making or a warning lesson? Am. J. Respir. Crit. Care Med. 188, 1-2. PMCID: PMC3735245

244. Welch, B.D., P. Yuan, S. Bose, C.A. Kors, R.A. Lamb and T.S. Jardetzky. (2013). Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain. PLoS Pathog. 9, e1003534. PMCID: PMC3738495

245. Roberts, K.L., G.P. Leser, C. Ma and R.A. Lamb. (2013). The amphipathic helix of influenza A virus M2 protein is required for filamentous bud formation and scission of filamentous and spherical particles. J. Virol. 87, 9973-9982. PMCID: PMC3754012

246. Rossman, J.S. and R.A. Lamb. (2013). Viral Membrane Scisson. Annu. Rev. Cell. Develop. Biol. 29, 551-569.

247. Ma, C., G. Fiorin, V. Carnevale, J. Wang, R.A. Lamb, M.L. Klein, Y. Wu, L.H. Pinto and W.F. DeGrado. (2013). Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus. Structure 21, 2033-2041. PMCID: PMC3927992

248. Rey-Carrizo, M., E. Torres, C. Ma, M. Barniol-Xicota, J. Wang, Y. Wu, L. Naesens, W.F. Degrado, R.A. Lamb, L.H. Pinto, and S. Vázquez. (2013). 3-azatetracyclo[5.2.1.15,8.01,5]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. J. Med. Chem. 56, 9265-9274. PMCID: PMC3889466

249. Bose, S., C.M. Heath, P.A. Shah, M. Alayyoubi, T.S. Jardetzky and R.A. Lamb. (2013). Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability. J. Virol. 87, 13520-13531. PMCID: PMC3838234

2014-back to top

250. Jardetzky, T.S. and R.A. Lamb.  (2014).  Activation of paramyxovirus membrane fusion and viral entry.  Curr. Opin. Virol. 5, 24-33. PMCID: PMC4028362

251. Bose, S., A.S. Song, T.S. Jardetzky and R.A. Lamb.  (2014).  Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells.  J. Virol. 88, 3925-3941. PMCID: PMC3993720

252. Poor, T.A., L.M. Jones, A. Sood, G.P. Leser, M.D. Plasencia, D.L. Rempel, T.S. Jardetzky, R.J. Woods, M.L. Gross and R.A. Lamb.  (2014).  Probing the paramyxovirus fusion (F) protein refolding event from pre- to postfusion by oxidative footprinting.  Proc. Natl. Acad. Sci. USA 111, E2596-E2605. PMCID: PMC4078851

253. Rey-Carrizo, M., M. Barniol-Xicota, C. Ma, M. Frigolé-Vivas, E. Torres, L. Naesens, S. Llabrés, J. Juárez-Jiménez, F.J. Luque, W.F. Degrado, R.A. Lamb, L.H. Pinto, and S. Vázquez.  (2014).  Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.  J. Med. Chem. 57, 5738-5747.  PMCID: PMC4096222

254. Bruns, A.M., G.P. Leser, R.A. Lamb and C.M. Horvath.  (2014).  The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.  Mol. Cell 55, 771-781.  PMCID: PMC4156907

255. Welch, B.D., M. Paduch, G.P. Leser, Z. Bergman, C.A. Kors, R.G. Paterson, T.S. Jardetzky, A.A. Kossiakoff and R.A. Lamb.  (2014).  Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies (sABs).  J. Virol. 88, 11713-11725. PMCID: PMC4178754

256. Lamb, R.A. and K.L. Roberts.  (2014).  Influenza (MS 654).  In, Reference Module in Biomedical Research, Chapter 02606, http://dx.doi.org/10.1016/B978-0-12-801238-3.02606-4

2015-back to top

257. Wu, Y., B. Canturk, H. Jo, C. Ma, E. Gianti, G. Fiorin, L.H. Pinto, R.A. Lamb, M.L. Klein, J. Wang and W.F. DeGrado.  (2014).  Flipping in the Pore: Discovery of Dual Inhibitors that Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.  J. Am. Chem. Soc. 136, 17987-17995.  PMCID: PMC4286326

258. Roberts, K.L., B. Manicassamy and R.A. Lamb.  (2015).  Influenza A virus uses intercellular connections to spread to neighboring cells.  J. Virol. 89, 1537-1549.  PMCID: PMC4300760

259. Poor, T.A., A.S. Song, B.D. Welch, C.A. Kors, T.S. Jardetzky and R.A. Lamb.  (2015).  On the stability of parainfluenza virus 5 F proteins.  J. Virol. 89, 3438-3441. PMCID: PMC4337539

260. Bose, S., T.S. Jardetzky and R.A. Lamb.  (2015).  Timing is everything: Fine-tuned molecular machines orchestrate paramyxovirus entry.  Virology 479-480C, 518-531. PMCID: PMC4424121

261. Alayyoubi, M., G.P. Leser, C.A. Kors and R.A. Lamb.  (2015).  Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex.  Proc. Natl. Acad. Sci. USA  112, E1792-E1799. PMCID: PMC4394319

262. Brennan, B., F. Weber, R. Kormelink, E. Schnettler, M. Bouloy, A.B. Failloux, S.C. Weaver, J.K. Fazakerley, R. Fragkoudis, M. Harris, J.N. Barr, P. Palese, A. García-Sastre, R.G. Dalziel, B.M. Dutia, A.C. Lowen, J. Steel, R.E. Randall, W.P. Duprex, C.M. Rice, R.B. Tesh, F.A. Murphy, H. Ebihara, P.F.C. Vasconcelos, M.R. Nunes, A.R. Fooks, G.L. Smith, I. Goodfellow, H.R. Pappu, R.A. Lamb, R.G. Paterson, S. Higgs, D.L. Vanlandingham, R.G. Dietzgen, J.S. Lodmell, S.T. Nichol, J. Daly, D.E. Ullman, A. Plyusnin, A. Plyusnina, A. Plyusnina, S. Efstathiou, R. Hewson, N. Tordo, S. Cherry, C. Boutell, M.J. Hosie, P.R. Murcia, J.C. Neil, M. Palmarini, A.H. Patel, B.J. Willett and A. Kohl.  (2015).  In memoriam, Richard M. Elliott (1954 – 2015): a tribute.  J. Gen. Virol. 96, 1975-1978

263. Li, Z., C. Hung, R.G. Paterson, F. Michel, S. Fuentes, R. Place, Y. Lin, R.J. Hogan, R.A. Lamb, B. He.  (2015).  Type II integral membrane protein, TM of J paramyxovirus promotes cell-to-cell fusion.  Proc. Natl. Acad. Sci. USA 112, 12504-12509. PMCID: PMC4603449

264. Wong, J.J.W., R.G. Paterson, R.A. Lamb and T.S. Jardetzky.  (2016).  Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form.  Proc. Natl. Acad. Sci. USA. 113, 1056-1061. PMCID: PMC4743799

265. Afonso, C.L., G.K. Amarasinghe, K. Bányai, Y. Bào, C.F. Basler, S. Bavari, N. Bejerman, K.R. Blasdell, F.-X. Briand, T. Briese, A.A. Bukreyev, C.H. Calisher, K. Chandran, J. Chéng, A.N. Clawson, P.L. Collins, R.G. Dietzgen, O. Dolnik, L.L. Domier, R. Dürrwald, J.M. Dye, A.J. Easton, H. Ebihara, S.L. Farkas, J. Freitas-Astúa, P. Formenty, R.A. Fouchier, Y. Fù, E. Ghedin, M.M. Goodin, R. Hewson, M. Horie, T.H. Hyndman, D. Ji?ng, E.W. Kitajima, G.P. Kobinger, H. Kondo, G. Kurath, R.A. Lamb, S. Lenardon, E.M. Leroy, C. L?, X. Lín, L. Liu, B. Longdon, S. Marton, A. Maisner, E. Mühlberger, S.V. Netesov, N. Nowotny, J.L. Patterson, S.L. Payne, J.T. Paweska, R.E. Randall, B.K. Rima, P. Rota, D. Rubbenstroth, M. Schwemmle, M. Shi, S.J. Smither, M. Stenglein, D.M. Stone, A. Takada, C. Terregino, R.B. Tesh, J. Tian, K. Tomonaga, N. Tordo, J.S. Towner, N. Vasilakis, M. Verbeek, V.E. Volchkov, V. Wahl-Jensen, J.A. Walsh, P.J. Walker, D.Wang, L.-F. Wang, T. Wetzel, A.E. Whitfield, J. Xiè, K.Y. Yuen, Y. Zh?ng and J.H. Kuhn.  2016. Taxonomy of the order Mononegavirales: update 2016.  Arch. Virol. 161, 2351-2360.  PMCID: PMC4947412

266. Wen, X., J. Pickens, J.J. Mousa, G.P. Leser, R.A. Lamb, J.E. Crowe and T.S. Jardetzky.  (2016).  A chimeric pneumovirus fusion protein carrying neutralizing epitopes of both MPV and RSV.  PLoS One 11, e0155917.  PMCID: PMC4880302

267. Song, A.S., T.A. Poor, L.A. Abriata, T.S. Jardetzky, M. Dal Peraro and R.A. Lamb.  (2016).  Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins.  Proc. Natl. Acad. Sci. USA 113, E3844-E3851.  PMCID: PMC4941503

268. Adu-Gyamfi, E., L.S. Kim, T.S. Jardetzky and R.A. Lamb.  (2016).  Mutagenesis of paramyxovirus hemagglutinin-neuraminidase membrane-proximal stalk region influences stability, receptor binding and neuraminidase activity.  J. Virol. 90, 7778-7788.  PMCID: PMC4988141

269. Adu-Gyamfi, E., L.S. Kim, T.S. Jardetzky and R.A. Lamb.  (2016).  Flexibility of the head-stalk linker domain of paramyxovirus HN glycoprotein is essential for triggering virus fusion.  J. Virol. 90, 9172-9181. PMCID: PMC5044854

2017-back to top

270. Wen, X., J.J. Mousa, J.T. Bates, R.A. Lamb, J.E. Crowe and T.S. Jardetzky.  (2016).  Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus.  Nat. Microbiol. 2, 16272.  PMCID: PMC5308794

271. Postler TS, A.N. Clawson, G.K. Amarasinghe, C.F. Basler, S. Bavari, M. Benk?, K.R. Blasdell, T. Briese, M.J. Buchmeier, A. Bukreyev, C.H. Calisher, K. Chandran, R. Charrel, C.S. Clegg, P.L. Collins, J.C. de la Torre, J.L. DeRisi, R.G. Dietzgen, O. Dolnik, R. Dürrwald, J.M. Dye, A.J. Easton, S. Emonet, P. Formenty, R.A. Fouchier, E. Ghedin, J.P. Gonzalez, B.Harrach, R. Hewson, M. Horie, D. Ji?ng, G. Kobinger, H. Kondo, A.M. Kropinski, M. Krupovic, G. Kurath, R.A. Lamb, E.M. Leroy, I.S. Lukashevich, A. Maisner, A.R. Mushegian, S.V. Netesov, N. Nowotny, J.L. Patterson, S.L. Payne, J.T. Paweska, C.J. Peters, S.R. Radoshitzky, B.K. Rima, V. Romanowski, D. Rubbenstroth, S. Sabanadzovic, H. Sanfaçon, M.S. Salvato, M. Schwemmle, S.J. Smither, M.D. Stenglein, D.M. Stone, A. Takada, R.B. Tesh, K. Tomonaga, N. Tordo, J.S. Towner, N. Vasilakis, V.E. Volchkov, V.  Wahl-Jensen, P.J. Walker, L.F. Wang, A. Varsani, A.E. Whitfield, F.M. Zerbini and J.H. Kuhn.  (2016).  Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials.  Syst. Biol. 66, 463-473

272. Leser, G.P. and R.A. Lamb. (2017).  Lateral organization of influenza virus proteins in the budzone region of the plasma membrane.  J. Virol. 91, e02104-e02116.  PMCID: PMC5391459

273. Amarasinghe, G.K., Y. Bào, C.F. Basler, S. Bavari, M. Beer, N. Bejerman, K.R. Blasdell, A. Bochnowski, T. Briese, A.A. Bukreyev, C.H. Calisher, K. Chandran, P.L. Collins, R.G. Dietzgen, O. Dolnik, R. Dürrwald, J.M. Dye, A.J. Easton, H. Ebihara, Q. Fang, P. Formenty, R.A. Fouchier, E. Ghedin, R.M. Harding, R. Hewson, C.M. Higgins, J. Hong, M. Horie, A.P. James, D. Ji?ng, G.P. Kobinger, H. Kondo, G. Kurath, R.A. Lamb, B. Lee, E.M. Leroy, M. Li, A. Maisner, E. Mühlberger, S.V. Netesov, N. Nowotny, J.L. Patterson, S.L. Payne, J.T. Paweska, M.N. Pearson, R.E. Randall, P.A. Revill, B.K. Rima, P. Rota, D. Rubbenstroth, M. Schwemmle, S.J. Smither, Q. Song, D.M. Stone, A. Takada, C. Terregino, R.B. Tesh, K. Tomonaga, N. Tordo, J.S. Towner, N. Vasilakis, V.E. Volchkov, V. Wahl-Jensen, P.J. Walker, B. Wang, D. Wang, F. Wang, L.-F. Wang, J.H. Werren, A.E. Whitfield, Z. Yan, G. Ye, and J.H. Kuhn.  2016. Taxonomy of the order Mononegavirales: update 2017.  Arch. Virol. 162, 2493-2504.

Back to Top

 

 

 

Home | Research | Publications | Lab Members | Newcomer's Checklist | Finding Us | Links | Join the Lamb Lab | NWU
Department of Molecular Biosciences

Lamb Lab Web Site
Created & Maintained by Barbara St. Cyr
Last Updated March 8, 2017